Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes.
Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes.
复制标题
DOI：
10.1111/adb.13134
复制
发表时间：
2022-03
影响因子：
3.4
通讯作者：
Olsen CM
中科院分区：
文献类型：
--
作者：
Muelbl MJ;Glaeser BL;Shah AS;Chiariello RA;Nawarawong NN;Stemper BD;Budde MD;Olsen CM
创伤性脑损伤（TBI）和药物成瘾是常见的合并症，但目前尚不清楚TBI的神经系统后遗症是否与这种关系有关。我们之前报道过，在接受反复爆炸性脑损伤（rbTBI）的大鼠中，羟考酮寻求在药物自我给药后升高。创伤性脑损伤和药物滥用均可改变结构和功能神经影像学结果，但尚不清楚损伤和药物暴露是否存在相互作用。为了确定创伤性脑损伤和羟考酮暴露的影响，我们对大鼠进行了创伤性脑损伤和羟考酮的自我给药，并测量了药物寻找和几种神经影像学指标。我们发现rbTBI和羟考酮对伏隔核（NAc）的分数各向异性（FA）有交互作用，并且内侧前额叶皮层（mPFC）的FA与药物寻找相关。我们还发现，损伤和药物对广泛的功能连通性和血氧水平依赖（BOLD）反应的区域均匀性具有交互作用，并且边缘下内侧前额叶皮层的半球内功能连通性与药物寻找呈正相关。综上所述，rbTBI和羟考酮自我给药对结构和功能磁共振成像（MRI）指标有交互作用，其中一些指标与药物寻找之间存在相关效应。这些数据支持创伤性脑损伤和阿片类药物暴露产生有助于成瘾倾向的神经适应的假设。我们之前发现反复爆炸创伤性脑损伤（rbTBI）在自我给药后增加了羟考酮的寻求。在这里，我们报告rbTBI和羟考酮自我给药对结构和功能神经影像学测量具有相互作用。分数各向异性与前边缘和边缘下前额叶皮层的药物寻求呈负相关，边缘下前额叶皮层的半球间连通性与药物寻求呈正相关。
Traumatic brain injury (TBI) and drug addiction are common comorbidities, but it is unknown if the neurological sequelae of TBI contribute to this relationship. We have previously reported elevated oxycodone seeking after drug self-administration in rats that received repeated blast TBI (rbTBI). TBI and exposure to drugs of abuse can each change structural and functional neuroimaging outcomes, but it is unknown if there are interactive effects of injury and drug exposure. To determine the effects of TBI and oxycodone exposure, we subjected rats to rbTBI and oxycodone self-administration and measured drug seeking and several neuroimaging measures. We found interactive effects of rbTBI and oxycodone on fractional anisotropy (FA) in the nucleus accumbens (NAc), and that FA in the medial prefrontal cortex (mPFC) was correlated with drug seeking. We also found an interactive effect of injury and drug on widespread functional connectivity and regional homogeneity of the blood oxygen level dependent (BOLD) response, and that intra-hemispheric functional connectivity in the infralimbic medial prefrontal cortex positively correlated with drug seeking. In conclusion, rbTBI and oxycodone self-administration had interactive effects on structural and functional magnetic resonance imaging (MRI) measures, and correlational effects were found between some of these measures and drug seeking. These data support the hypothesis that TBI and opioid exposure produce neuroadaptations that contribute to addiction liability. We previously found that repeated blast traumatic brain injury (rbTBI) increases oxycodone seeking after self-administration. Here, we report that rbTBI and oxycodone self-administration have interactive effects on structural and functional neuroimaging measures. Fractional anisotropy negatively correlated with drug seeking in the prelimbic and infralimbic prefrontal cortex, and interhemispheric connectivity of the infralimbic prefrontal cortex positively correlated with drug seeking.
登录
查看更多内容
影响因子：
4.8
作者：
Kaushal, Mayank;Espana, Lezlie Y.;Meier, Timothy B.
通讯作者：
Meier, Timothy B.
影响因子：
3.3
作者：
Blackwood, Christopher A.;Leary, Michael;Cadet, Jean Lud
通讯作者：
Cadet, Jean Lud
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
影响因子：
5.7
作者：
Caeyenberghs, Karen;Verhelst, Helena;Wilson, Peter H.
通讯作者：
Wilson, Peter H.