NOD1 and NOD2 Signaling in Infection and Inflammation.
NOD1 and NOD2 Signaling in Infection and Inflammation.
复制标题
DOI：
10.3389/fimmu.2012.00328
复制
发表时间：
2012
影响因子：
7.3
通讯作者：
Zamboni DS
中科院分区：
文献类型：
--
作者：
Moreira LO;Zamboni DS
感测细胞内病原体是由先天免疫细胞介导的过程，其对于诱导炎症过程和针对病原微生物的有效适应性免疫应答至关重要。NOD样受体（NLR）包括细胞内模式识别受体家族，其对于损伤和微生物相关分子模式的识别是重要的。NOD1和NOD2是参与识别能够在细胞内侵入和繁殖的病原微生物亚群的特化NLR。一旦被激活，这些分子就会触发细胞内信号传导途径，导致转录反应的激活，最终导致炎症基因亚组的表达。在这篇综述中，我们将重点介绍NOD1和NOD2在识别和响应细胞内病原体（包括革兰氏阳性和革兰氏阴性细菌）中的作用，以及它们响应不含肽聚糖的病原体（如病毒和原生动物寄生虫）的信号能力。
Sensing intracellular pathogens is a process mediated by innate immune cells that is crucial for the induction of inflammatory processes and effective adaptive immune responses against pathogenic microbes. NOD-like receptors (NLRs) comprise a family of intracellular pattern recognition receptors that are important for the recognition of damage and microbial-associated molecular patterns. NOD1 and NOD2 are specialized NLRs that participate in the recognition of a subset of pathogenic microorganisms that are able to invade and multiply intracellularly. Once activated, these molecules trigger intracellular signaling pathways that lead to the activation of transcriptional responses culminating in the expression of a subset of inflammatory genes. In this review, we will focus on the role of NOD1 and NOD2 in the recognition and response to intracellular pathogens, including Gram-positive and Gram-negative bacteria, and on their ability to signal in response to non-peptidoglycan-containing pathogens, such as viruses and protozoan parasites.
登录
查看更多内容
影响因子：
5.4
作者：
Berrington, William R.;Iyer, Ravi;Wells, Richard D.;Smith, Kelly D.;Skerrett, Shawn J.;Hawn, Thomas R.
通讯作者：
Hawn, Thomas R.
DOI：
10.1086/651559
发表时间：
2010-05-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Berrington WR;Macdonald M;Khadge S;Sapkota BR;Janer M;Hagge DA;Kaplan G;Hawn TR
通讯作者：
Hawn TR
影响因子：
32.4
作者：
Bertrand, Mathieu J. M.;Doiron, Karine;Saleh, Maya
通讯作者：
Saleh, Maya
DOI：
10.4269/ajtmh.2009.80.718
发表时间：
2009-05-01
影响因子：
3.3
作者：
Finney, Constance A. M.;Lu, Ziyue;Kain, Kevin C.
通讯作者：
Kain, Kevin C.
影响因子：
4.8
作者：
Anand, Paras K.;Tait, Stephen W. G.;Kanneganti, Thirumala-Devi
通讯作者：
Kanneganti, Thirumala-Devi