Cross fostering experiments suggest that mice songs are innate.
Cross fostering experiments suggest that mice songs are innate.
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DOI：
10.1371/journal.pone.0017721
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发表时间：
2011-03-09
期刊：
影响因子：
3.7
通讯作者：
Okanoya K
中科院分区：
文献类型：
--
作者：
Kikusui T;Nakanishi K;Nakagawa R;Nagasawa M;Mogi K;Okanoya K
声音学习是人类语言的一个重要功能组成部分，最近的研究表明，成年雄性小鼠发出的超声声音序列的特征是“歌曲”，这表明小鼠的超声求爱声音提供了一个哺乳动物的声音学习模型。我们测试了老鼠的歌曲是否学习，通过检查饲养环境中的交叉培养实验的相对作用。我们发现，C57 BL/6和BALB/c雄性发出一个明显不同的模式的歌曲与不同的频率和音节组成; C57 BL/6雄性表现出较高的峰值频率的音节，较短的音节之间的间隔，和更多的向上频率调制跳跃，而BALB/c雄性产生更多的“V形”和“谐波”音节。为了确定环境对小鼠鸣叫发育的影响程度，将这两个品系的儿子与另一个品系的父母交叉培养。当这些交叉寄养的幼鼠完全发育时，他们的歌声被记录下来，并将它们的歌声与遗传父母饲养的雄性小鼠的歌声进行比较。交叉培养的动物唱歌的声学特征-包括音节间隔，峰值频率和调制模式-与它们的遗传父母相似。此外，他们的歌曲元素保留了与他们的遗传父母的歌曲相似的序列特征。这些结果并不支持老鼠的“歌声”是习得的这一假设;在本实验条件下，我们没有发现任何声音学习的证据。我们的观察，应变特定字符的歌曲配置文件仍然存在，即使在改变发展的听觉环境表明，这些求爱的声音序列的结构是强大的遗传控制。因此，小鼠的“歌曲”作为哺乳动物的声音学习模型的有用性是有限的，但小鼠的歌曲有可能成为一个不可或缺的模型，研究遗传机制的声音模式和行为序列。
Vocal learning is a central functional constituent of human speech, and recent studies showing that adult male mice emit ultrasonic sound sequences characterized as “songs” have suggested that the ultrasonic courtship sounds of mice provide a mammalian model of vocal learning. We tested whether mouse songs are learned, by examining the relative role of rearing environment in a cross-fostering experiment. We found that C57BL/6 and BALB/c males emit a clearly different pattern of songs with different frequency and syllable compositions; C57BL/6 males showed a higher peak frequency of syllables, shorter intervals between syllables, and more upward frequency modulations with jumps, whereas BALB/c males produced more “chevron” and “harmonics” syllables. To establish the degree of environmental influences in mouse song development, sons of these two strains were cross-fostered to another strain of parents. Songs were recorded when these cross-fostered pups were fully developed and their songs were compared with those of male mice reared by the genetic parents. The cross-fostered animals sang songs with acoustic characteristics - including syllable interval, peak frequency, and modulation patterns - similar to those of their genetic parents. In addition their song elements retained sequential characteristics similar to those of their genetic parents' songs. These results do not support the hypothesis that mouse “song” is learned; we found no evidence for vocal learning of any sort under the conditions of this experiment. Our observation that the strain-specific character of the song profile persisted even after changing the developmental auditory environment suggests that the structure of these courtship sound sequences is under strong genetic control. Thus, the usefulness of mouse “song” as a model of mammalian vocal learning is limited, but mouse song has the potential to be an indispensable model to study genetic mechanisms for vocal patterning and behavioral sequences.
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影响因子：
2.2
作者：
NOIROT, E
通讯作者：
NOIROT, E
影响因子：
2.5
作者：
Musolf, Kerstin;Hoffmann, Frauke;Penn, Dustin J.
通讯作者：
Penn, Dustin J.
自闭症中观察到的人类15q11-13重复的染色体工程小鼠模型中的异常行为。
影响因子：
64.5
作者：
Nakatani J;Tamada K;Hatanaka F;Ise S;Ohta H;Inoue K;Tomonaga S;Watanabe Y;Chung YJ;Banerjee R;Iwamoto K;Kato T;Okazawa M;Yamauchi K;Tanda K;Takao K;Miyakawa T;Bradley A;Takumi T
通讯作者：
Takumi T
DOI：
10.1016/s0065-3454(08)60377-0
发表时间：
1997-01-01
期刊：
ADVANCES IN THE STUDY OF BEHAVIOR, VOL 26
影响因子：
--
作者：
Janik, Vincent M.;Slater, Peter J. B.
通讯作者：
Slater, Peter J. B.
影响因子：
9.8
作者：
Holy TE;Guo Z
通讯作者：
Guo Z