Climacteric in untreated isolated growth hormone deficiency.
Climacteric in untreated isolated growth hormone deficiency.
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未经治疗的孤立性生长激素缺乏症的更年期。
DOI：
10.1097/gme.0b013e31815b97d4
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Aguiar-Oliveira,ManuelH
中科院分区：
文献类型：
--
作者：
Menezes,Menilson;Salvatori,Roberto;Oliveira,CarlaRP;Pereira,RossanaMC;Souza,AnitaHO;Nobrega,LucianaMA;Cruz,EdlaAC;Menezes,Marcos;Alves,EricaO;Aguiar-Oliveira,ManuelH
目的：研究的时间，症状的强度，激素的配置文件，更年期的妇女与未经治疗的孤立的生长激素（GH）缺乏症（IGHDhides.Design）的相关发病率：妇女属于一个大的巴西家族IGHD由于GH释放激素受体基因的纯合突变进行了研究。他们都没有接受过GH替代治疗。进行两步方案。在第一个病例对照实验中，旨在确定更年期的年龄，我们比较了8名IGHD女性和32名年龄在37岁至55岁之间的正常女性。在第二个横断面实验中，旨在确定更年期症状的严重程度，7名IGHD女性（年龄47-65岁）与13名对照组（年龄44-65岁）进行了比较。Kupperman指数评分，血清卵泡刺激素，促黄体生成素，催乳素，雌二醇水平进行了测定，盆腔和乳腺超声检查，乳腺X线摄影，阴道细胞学检查were performed.Results：卵泡刺激素高于20 mIU/mL的妇女人数高于IGHD的妇女比对照组。Kupperman指数在两组之间没有差异。患有IGHD的女性月经初潮延迟，产次较低。激素水平相似，但IGHD女性的催乳素较低。IGHD女性的子宫体积较小，两组的子宫内膜厚度和卵巢体积相似。两组之间的乳房图像或阴道细胞学观察无差异。结论：月经初潮延迟和更年期的开始是预期在未经治疗的一生IGHD，但更年期症状和激素的配置文件类似于正常的更年期。
Objective:To study the time, intensity of symptoms, hormonal profile, and related morbidity of climacteric in women with untreated isolated growth hormone (GH) deficiency (IGHD).Design:Women belonging to a large Brazilian kindred with IGHD due to a homozygous mutation in the GH-releasing hormone receptor gene were studied. None of them had ever received GH replacement therapy. A two-step protocol was performed. In the first case-control experiment, aimed to determine the age at climacteric, we compared eight women with IGHD and 32 normal women between 37 and 55 years of age. In the second cross-sectional experiment, aimed to determine the severity of climacteric symptoms, seven women with IGHD (aged 47-65 y) were compared with 13 controls (aged 44-65 y). The Kupperman Index scores, serum follicle-stimulating hormone, luteinizing hormone, prolactin, and estradiol levels were determined, and pelvic and mammary ultrasonography, mammography, and colpocytology were performed.Results:The number of women with follicle-stimulating hormone above 20 mIU/mL was higher in women with IGHD than controls. Kupperman's Index was not different between the two groups. Menarche had been delayed and parity was lower in women with IGHD. Hormonal profile was similar, but prolactin was lower in women with IGHD. Uterine volume was smaller in women with IGHD, and endometrial thickness and ovarian volume were similar in the two groups. No difference in breast images or in colpocytology was observed between the two groups.Conclusions:Menarche was delayed and the beginning of climacteric is anticipated in untreated lifetime IGHD, but menopausal symptoms and hormonal profile resemble the normal climacteric.
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DOI：
10.1016/0006-291x(82)90614-3
发表时间：
1982
影响因子：
3.1
作者：
Benoit,R;Ling,N;Alford,B;Guillemin,R
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影响因子：
2.5
作者：
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通讯作者：
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影响因子：
2.5
作者：
GAARSKJAER, FB
通讯作者：
GAARSKJAER, FB
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影响因子：
2.5
作者：
Sadao Shiosaka;K. Takatsuki;M. Sakanaka;S. Inagaki;H. Takagi;E. Senba;Y. Kawai;H. Iida;H. Minagawa;Y. Hara;T. Matsuzaki;M. Tohyama
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DOI：
--
发表时间：
1978
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
J. Zimmer;F. Haug
通讯作者：
F. Haug