Dyslipidemia in rural areas of North China: prevalence, characteristics, and predictive value.
Dyslipidemia in rural areas of North China: prevalence, characteristics, and predictive value.
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华北农村地区血脂异常：患病率、特征及预测价值。
DOI：
10.1186/s12944-016-0328-y
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发表时间：
2016-09-13
影响因子：
4.5
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Gao N;Yu Y;Zhang B;Yuan Z;Zhang H;Song Y;Zhao M;Ji J;Liu L;Xu C;Zhao J
背景心血管疾病的患病率在世界范围内呈上升趋势。血脂异常作为一种常见的致病危险因素，在这些疾病的发生和发展中起着重要作用。我们进行了调查，以实现准确和最新的信息，血脂异常的患病率及其与其他脂质相关疾病在农村华北地区。MethodsUsing一个复杂的，多阶段的，概率抽样设计，我们进行了大规模的横断面研究，8528名农村参与者年龄在18岁以上的山东省。阐述了血脂异常的患病率和特点。血脂异常类型和脂质相关疾病之间的比值比进一步分析logistic regression.ResultsAmong the overall population，45.8%患有血脂异常。总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）胆固醇和甘油三酯（TG）血脂异常（包括高水平和极高水平）的患病率分别为18.6%、12.7%、9.8%和12.7%。在所有患有血脂异常的参与者中，23.9%的人知道，只有11.5%的人接受了治疗，10.0%的人得到了控制。对于血脂异常的受试者，非酒精性脂肪性肝病（NAFLD）的风险最高，是非血脂异常的3.3倍。其次为高尿酸血症和糖尿病（DM），与正常对照组相比增加2倍（OR = 1.99，P < 0.001; OR = 1.92，P < 0.001）;动脉粥样硬化（AS）危险性仅为1.5倍（OR = 1.47，P < 0.001）。高胆固醇主要与AS相关，而TG异常与NAFLD和DM相关。结论血脂异常已成为中国北方农村地区严重的公共卫生问题。高TC的迅速增加和高TG风险的增加可能是导致AS、NAFLD和DM流行的原因之一。根据血脂异常表型制定个体化防治指南势在必行。
BackgroundThe prevalence of cardiovascular disease has been increasing worldwide. As a common pathogenic risk factor, dyslipidemia played a great role in the incidence and progress of these diseases. We investigated to achieve accurate and up-to-date information on the prevalence of dyslipidemia and its associations with other lipid-related diseases in rural North China.MethodsUsing a complex, multistage, probability sampling design, we conducted a large-scale cross-sectional study of 8528 rural participants aged over 18 years in Shandong Province. Prevalence and characteristics of dyslipidemia were demonstrated. The odds ratios between dyslipidemia types and lipid-related diseases were further analyzed by logistic regression.ResultsAmong the overall population, 45.8 % suffered from dyslipidemia. The prevalence of lipid abnormality (including high and very high levels) was 18.6, 12.7, 9.8 and 12.7 % for total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol and triglycerides (TG), respectively. Among all participants with dyslipidemia, 23.9 % were aware, only 11.5 % were treated, 10.0 % were controlled. For subjects with dyslipidemia, the risk for non-alcoholic fatty liver disease (NAFLD) was highest with a 3.3-fold over that of non-dyslipidmia (OR = 3.30,P< 0.001); followed by hyperuricemia and diabetes mellitus (DM), while with 2-fold increase (OR = 1.99,P< 0.001; OR = 1.92,P< 0.001); with only 1.5-fold risk for atherosclerosis (AS) (OR = 1.47,P< 0.001). The presence of high cholesterol was mainly associated with AS, while abnormal TG was correlated with NAFLD and DM.ConclusionsDyslipidemia has become a serious public health issue in rural North China. The rapid increase of high TC and incremental risk of high TG may contribute to the epidemic of AS, NAFLD and DM. It is imperative to develop individualized prevention and treatment guidelines according to dyslipidemia phenotypes.
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影响因子：
4.2
作者：
Cohen DE;Fisher EA
通讯作者：
Fisher EA
影响因子：
2.8
作者：
Fang P;Han S;Zhao L;Fang Z;Zhang Y;Zou X
通讯作者：
Zou X
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作者：
Assy, N;Kaita, K;Minuk, G
通讯作者：
Minuk, G
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Paramsothy, Pathmaja;Knopp, Robert H.;Heckbert, Susan R.
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Heckbert, Susan R.
中国酒精性和非酒精性脂肪肝流行病学
影响因子：
4.1
作者：
Fan, Jian-Gao
通讯作者：
Fan, Jian-Gao