Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia.
Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia.
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DOI：
10.1080/13554794.2010.547505
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发表时间：
2011-12
期刊：
影响因子：
0.8
通讯作者：
Papanicolaou AC
中科院分区：
文献类型：
--
作者：
Breier JI;Juranek J;Papanicolaou AC
一例继发于左半球单侧卒中的慢性失语症患者在4个时间点接受了语言测试、弥散张量成像（DTI）和脑磁图（MEG）功能成像：约束诱导语言治疗（CILT）前3周、治疗前即刻、治疗后即刻和治疗后3个月。语言测试，包括视觉命名和重复口语句子的性能之间的改善之前和之后立即CILT测试会议，但不是前CILT会议之间。在治疗后，左半球和右半球的同源区域的假定发病前语言区域的MEG激活立即增加，双侧弓状束内的完整性也增加。这些变化在两次CILT前会议之间并不明显。虽然这些功能，神经生理和结构变化中的一些在治疗后3个月消退，但所有这些变化均保持在基线水平或高于基线水平。结果提供的证据之间的关联的功能状态的改善和增加的完整性内的白色物质道已知参与语言功能和其对侧同源物，以及增加神经生理活动的地区，有可能subserve双边语言功能。
A patient with chronic aphasia secondary to unilateral stroke in the left hemisphere underwent language testing, diffusion tensor imaging (DTI), and functional imaging using magnetoencephalography (MEG) at four time points: 3 weeks prior to, immediately prior to, immediately after, and 3 months after Constraint Induced Language Therapy (CILT). Performance on language tests involving visual naming and repetition of spoken sentences improved between the immediately prior to and immediately after CILT testing sessions, but not between the pre-CILT sessions. MEG activation in putative pre-morbid language areas of the left hemisphere and homotopic areas of the right hemisphere increased immediately after therapy, as did integrity within the arcuate fasciculus bilaterally. These changes were not evident between the two pre-CILT sessions. While some of these functional, neurophysiological and structural changes had regressed 3 months after therapy, all remained at or above baseline levels. Results provide evidence for an association between improvement in functional status and the increased integrity within a white matter tract known to be involved in language function and its contralateral homologue, as well as increased neurophysiological activity in areas that have the potential to subserve language function bilaterally.
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