Histamine Ingestion by Anopheles stephensi Alters Important Vector Transmission Behaviors and Infection Success with Diverse Plasmodium Species.
Histamine Ingestion by Anopheles stephensi Alters Important Vector Transmission Behaviors and Infection Success with Diverse Plasmodium Species.
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DOI：
10.3390/biom11050719
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发表时间：
2021-05-11
期刊：
影响因子：
5.5
通讯作者：
Luckhart S
中科院分区：
文献类型：
--
作者：
Rodriguez AM;Hambly MG;Jandu S;Simão-Gurge R;Lowder C;Lewis EE;Riffell JA;Luckhart S
2019 年，估计全球有 2.29 亿人受到疟疾影响。疟疾寄生虫（疟原虫属）的传播媒介是按蚊，因此它们的行为、感染成功率和最终传播非常重要。患有严重疟疾的个体可能表现出血液中组胺浓度显着升高，组胺是人类的过敏介质，也是重要的昆虫神经调节剂，可能在吸血过程中传递给蚊子。为了确定摄入的组胺是否会改变史氏按蚊的生物学特性，我们提供了正常血液水平和与严重疟疾一致的水平的组胺，并监测了成年雌性史氏按蚊的吸血行为、飞行活动、触角和视网膜对宿主刺激的反应以及寿命。为了确定摄入的组胺对寄生虫感染成功的影响，我们对感染约氏疟原虫和恶性疟原虫的蚊子的中肠卵囊和唾液腺子孢子进行了定量。我们的数据显示，配置 An。含有与严重疟疾水平一致的组胺的斯蒂芬氏菌可以增强蚊子的行为和寄生虫感染的成功率，从而预计会放大寄生虫与人类宿主之间的传播。这些知识可用于将临床干预措施与通过降低组胺升高来减轻人类疾病病理学的临床干预措施与提供新的诱饵以改善疟疾控制联系起来。
An estimated 229 million people worldwide were impacted by malaria in 2019. The vectors of malaria parasites (Plasmodium spp.) are Anopheles mosquitoes, making their behavior, infection success, and ultimately transmission of great importance. Individuals with severe malaria can exhibit significantly increased blood concentrations of histamine, an allergic mediator in humans and an important insect neuromodulator, potentially delivered to mosquitoes during blood-feeding. To determine whether ingested histamine could alter Anopheles stephensi biology, we provisioned histamine at normal blood levels and at levels consistent with severe malaria and monitored blood-feeding behavior, flight activity, antennal and retinal responses to host stimuli and lifespan of adult female Anopheles stephensi. To determine the effects of ingested histamine on parasite infection success, we quantified midgut oocysts and salivary gland sporozoites in mosquitoes infected with Plasmodium yoelii and Plasmodium falciparum. Our data show that provisioning An. stephensi with histamine at levels consistent with severe malaria can enhance mosquito behaviors and parasite infection success in a manner that would be expected to amplify parasite transmission to and from human hosts. Such knowledge could be used to connect clinical interventions by reducing elevated histamine to mitigate human disease pathology with the delivery of novel lures for improved malaria control.
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影响因子：
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DOI：
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