Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy.
Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy.
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DOI：
10.1155/2014/595493
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发表时间：
2014
影响因子：
--
通讯作者：
Nojima Y
中科院分区：
文献类型：
--
作者：
Maeshima A;Nakasatomi M;Nojima Y
肾脏在遭受各种损伤后具有再生和修复的能力。在过去的几十年里，促进受损肾脏修复的因素已被广泛研究。通过使用肾损伤动物模型，研究了内在和外在生长因子、转录因子和细胞外基质在此过程中的作用。成人肾脏和胚胎肾脏中肾干细胞的鉴定是一个活跃的研究领域。在正常肾脏的肾小管、间质和肾小球中发现了表达假定的干细胞标记或具有干细胞特性的细胞群。使用骨髓源性造血干细胞、间充质干细胞、内皮祖细胞和羊水源性干细胞进行的细胞疗法对于治疗动物急性或慢性肾衰竭非常有效。胚胎干细胞和诱导多能干细胞也用于构建人工肾或肾脏组件。在这篇综述中，我们从促肾因子、肾干/祖细胞和干细胞疗法的角度重点介绍肾脏再生医学的进展，并讨论实现人类肾脏疾病再生治疗需要解决的问题。
The kidney has the capacity for regeneration and repair after a variety of insults. Over the past few decades, factors that promote repair of the injured kidney have been extensively investigated. By using kidney injury animal models, the role of intrinsic and extrinsic growth factors, transcription factors, and extracellular matrix in this process has been examined. The identification of renal stem cells in the adult kidney as well as in the embryonic kidney is an active area of research. Cell populations expressing putative stem cell markers or possessing stem cell properties have been found in the tubules, interstitium, and glomeruli of the normal kidney. Cell therapies with bone marrow-derived hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, and amniotic fluid-derived stem cells have been highly effective for the treatment of acute or chronic renal failure in animals. Embryonic stem cells and induced pluripotent stem cells are also utilized for the construction of artificial kidneys or renal components. In this review, we highlight the advances in regenerative medicine for the kidney from the perspective of renotropic factors, renal stem/progenitor cells, and stem cell therapies and discuss the issues to be solved to realize regenerative therapy for kidney diseases in humans.
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