Antibiofilm polysaccharides.

Antibiofilm polysaccharides.
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DOI:
10.1111/j.1462-2920.2012.02810.x
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发表时间:
2013-02
影响因子:
5.1
通讯作者:
Ghigo JM
Ghigo JM
中科院分区:
生物学2区
文献类型:
--
作者:
Rendueles O;Kaplan JB;Ghigo JM

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细菌胞外多糖已被证明介导许多细胞与细胞和细胞与表面的相互作用,这些相互作用是细菌生物膜形成、内聚和稳定所必需的。然而,最近的研究已经确定了几种细菌多糖在体外和体内抑制细菌和真菌的生物膜形成。本文综述了最近在细菌和真核生物中发现的抗生物膜多糖的组成、作用方式和潜在的生物学作用。其中一些分子可能在工业和医学上作为抗生物膜剂具有技术应用。
Bacterial extracellular polysaccharides have been shown to mediate many of the cell-to cell and cell-to-surface interactions that are required for the formation, cohesion and stabilization of bacterial biofilms. However, recent studies have identified several bacterial polysaccharides that inhibit biofilm formation by a wide-spectrum of bacteria and fungi both in vitro and in vivo. This review discusses the composition, modes of action, and potential biological roles of antibiofilm polysaccharides recently identified in bacteria and eukaria. Some of these molecules may have technological applications as antibiofilm agents in industry and medicine.
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