Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern.
Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern.
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DOI：
10.1016/j.ajpath.2021.03.004
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Musser JM
中科院分区：
文献类型：
--
作者：
Long SW;Olsen RJ;Christensen PA;Subedi S;Olson R;Davis JJ;Saavedra MO;Yerramilli P;Pruitt L;Reppond K;Shyer MN;Cambric J;Finkelstein IJ;Gollihar J;Musser JM
自严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）大流行开始以来，国际上一直关注出现的病毒变体，其突变会增加传播性，增强对人类免疫反应的逃避，或以其他方式改变重要的生物学表型。2020年底，全球出现了几个令人担忧的变体，包括英国变体（B.1.1.7）、南非变体（B.1.351）、巴西变体（P.1和P.2），以及两个相关的加州变体（B.1.429和B.1.427）。这些变异被认为具有增强的传播性。对于南非和巴西的变种，有证据表明刺突蛋白的突变允许它从一些疫苗和治疗性单克隆抗体中逃脱。根据我们广泛的基因组测序计划，涉及2020年3月至2021年2月收集的20,453例2019冠状病毒疾病患者样本，我们报告在居住在大都市区的休斯顿卫公会医院（Houston， TX）患者中发现了所有六种SARS-CoV-2变体。尽管这些变异目前在人群中发病率相对较低（总计1.1%），但它们在地理上分布广泛。休斯顿是美国第一个通过基因组测序记录了所有六种当前关注的变体的活跃循环的城市。随着疫苗部署的加快，加强对SARS-CoV-2的基因组监测对于了解相应变体的存在、频率和医疗影响及其传播模式和轨迹至关重要。
Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there has been international concern about the emergence of virus variants with mutations that increase transmissibility, enhance escape from the human immune response, or otherwise alter biologically important phenotypes. In late 2020, several variants of concern emerged globally, including the UK variant (B.1.1.7), the South Africa variant (B.1.351), Brazil variants (P.1 and P.2), and two related California variants of interest (B.1.429 and B.1.427). These variants are believed to have enhanced transmissibility. For the South Africa and Brazil variants, there is evidence that mutations in spike protein permit it to escape from some vaccines and therapeutic monoclonal antibodies. On the basis of our extensive genome sequencing program involving 20,453 coronavirus disease 2019 patient samples collected from March 2020 to February 2021, we report identification of all six of these SARS-CoV-2 variants among Houston Methodist Hospital (Houston, TX) patients residing in the greater metropolitan area. Although these variants are currently at relatively low frequency (aggregate of 1.1%) in the population, they are geographically widespread. Houston is the first city in the United States in which active circulation of all six current variants of concern has been documented by genome sequencing. As vaccine deployment accelerates, increased genomic surveillance of SARS-CoV-2 is essential to understanding the presence, frequency, and medical impact of consequential variants and their patterns and trajectory of dissemination.
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影响因子：
6.4
作者：
Long SW;Olsen RJ;Eagar TN;Beres SB;Zhao P;Davis JJ;Brettin T;Xia F;Musser JM
通讯作者：
Musser JM
DOI：
10.1056/nejmoa2029849
发表时间：
2021-01-21
期刊：
The New England journal of medicine
影响因子：
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影响因子：
28.3
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影响因子：
168.9
作者：
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通讯作者：
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影响因子：
6.4
作者：
Long, S. Wesley;Beres, Stephen B.;Musser, James M.
通讯作者：
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