Hemodynamic effects of infusion versus bolus administration of atrial natriuretic factor.
Hemodynamic effects of infusion versus bolus administration of atrial natriuretic factor.
复制标题
心房钠尿因子输注与推注给药的血流动力学影响。
作者：
R. Lappe;J. A. Todt;R. Wendt
The cardiovascular responses to intravenous bolus administration of several synthetic atrial natriuretic peptides were examined in conscious spontaneously hypertensive rats and compared with the hemodynamic effects of continuous infusions of the peptides. Rats were instrumented with pulsed Doppler flow probes to allow measurement of regional blood flow in the conscious, unrestrained hypertensive rat. Bolus administration of increasing doses (0.036-18 nmol/kg) of atriopeptin II, alpha-rat atrial natriuretic peptide, Wy-47,663, or alpha-human atrial natriuretic peptide caused short-lived, dose-dependent reductions in mean arterial pressure and renal vascular resistance. A marked but transient (10-40 seconds) increase in renal blood flow was observed after administration of the peptides. Mesenteric and hindquarter vasodilation also were observed after bolus injection of high doses of the atrial peptides. Infusion of alpha-rat atrial natriuretic peptide or Wy-47,663 (0.045-1.44 nmol/kg/min) resulted in sustained reductions in mean arterial pressure. The fall in arterial pressure was accompanied by significant reductions in regional blood flow in the renal, mesenteric, and hindquarter vascular beds. Dose-dependent increases in regional vascular resistances were observed in all three vascular beds during the peptide infusions. These data indicate that the hemodynamic responses to synthetic atrial peptides are greatly dependent on the mode of administration of the peptide in conscious spontaneously hypertensive rats. Stable, sustained responses were observed only during infusion steady state conditions.
心房钠尿因子抑制脱水和出血引起的加压素释放。
影响因子：
4.1
作者：
Samson,WK
通讯作者：
Samson,WK
具有生物活性的心房肽。
DOI：
10.1172/jci112206
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Ballerman,BJ;Brenner,BM
通讯作者：
Brenner,BM
Atriopeptin II 会降低清醒羊的心输出量。
DOI：
10.1152/ajpregu.1985.249.6.r776
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Breuhaus,BA;Saneii,HH;Brandt,MA;Chimoskey,JE
通讯作者：
Chimoskey,JE