Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases.

Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases.
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DOI:
10.3389/fragi.2022.884321
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发表时间:
2022
期刊:
影响因子:
--
通讯作者:
Lau, Edward
Lau, Edward
中科院分区:
其他
文献类型:
--
作者:
Srivastava, Himangi;Pozzoli, Marina;Lau, Edward

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近年来,人们发现越来越多的心脏分泌信号蛋白在不同的病理生理过程中发挥细胞通讯作用。这篇小综述简要讨论了心肌因子在衰老和年龄相关疾病的系统调节中的作用的当前证据。对人类转录组和分泌组数据的分析表明,许多其他心脏因子仍有待发现,它们可能在长期生理调节中发挥作用。我们讨论了阐明内分泌调节中心肌因子的身份和功能所面临的持续挑战和新兴技术。
In recent years an expanding collection of heart-secreted signaling proteins have been discovered that play cellular communication roles in diverse pathophysiological processes. This minireview briefly discusses current evidence for the roles of cardiokines in systemic regulation of aging and age-associated diseases. An analysis of human transcriptome and secretome data suggests the possibility that many other cardiokines remain to be discovered that may function in long-range physiological regulations. We discuss the ongoing challenges and emerging technologies for elucidating the identity and function of cardiokines in endocrine regulations.
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