Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.
Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.
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DOI：
10.1016/j.neulet.2011.02.056
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发表时间：
2011-04-20
影响因子：
2.5
通讯作者：
Tosini G
中科院分区：
文献类型：
--
作者：
Alcantara-Contreras S;Baba K;Tosini G
先前的研究表明，褪黑素在降低眼压方面有效，它还可能保护神经节细胞。我们最近报道，在缺乏褪黑素受体1型的小鼠中，25%-30%的神经节细胞在18个月大时死亡，这表明这些受体可能对神经节细胞的生存至关重要。在这项研究中，我们表明神经节细胞的丢失是褪黑素受体1型敲除所特有的，因为缺乏褪黑素受体2型的小鼠在衰老过程中神经节细胞的数量没有显示出任何显着的变化。此外，我们报告了褪黑激素1型受体敲除小鼠在3个月和12个月大时比对照组或2型褪黑素受体敲除小鼠有更高的夜间眼压。最后，我们的数据表明，外源性褪黑素在野生型中应用，而不是在1型褪黑素受体敲除中使用，可以显著降低眼压。我们的研究表明，在褪黑激素受体1型基因敲除小鼠中观察到的神经节细胞活性降低可能是夜间眼压升高的结果，因此提示夜间眼压水平和褪黑素信号应被认为是青光眼发病的危险因素。
Previous studies have demonstrated that melatonin is effective in lowering intraocular pressure and that it may also protect ganglion cells. We have recently reported that, in mice lacking the melatonin receptors type 1, 25–30% ganglion cells die out by 18 months of age, suggesting that these receptors might be important for ganglion cells survival. In this study we show that the loss of ganglion cells is specific for melatonin receptors type 1 knock-out since mice lacking the melatonin receptors type 2 did not show any significant change in the number ganglion cells during aging. Furthermore, we report that melatonin receptors type 1 knock-out mice have higher intraocular pressure during the nocturnal hours than control or melatonin receptors type 2 knock-out mice at 3 and 12 months of age. Finally, our data indicate that administration of exogenous melatonin in wild-type, but not in melatonin receptors type 1 knock-out, can significantly reduce intraocular pressure. Our studies indicate that the decreased viability of ganglion cells observed in melatonin receptors type 1 knock-out mice may be a consequence of the increases in the nocturnal intraocular pressure thus suggesting that intraocular pressure levels at night and melatonin signaling should be considered as risk factor in the pathogenesis of glaucoma.
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影响因子：
4.1
作者：
Meyer, P;Pache, M;Savaskan, E
通讯作者：
Savaskan, E
影响因子：
7.3
作者：
Pintor, J;Pel치ez, T;Peral, A
通讯作者：
Peral, A
影响因子：
3.8
作者：
Johnson TV;Tomarev SI
通讯作者：
Tomarev SI
DOI：
10.1073/pnas.0904400106
发表时间：
2009-09-01
影响因子：
11.1
作者：
Baba, Kenkichi;Pozdeyev, Nikita;Tosini, Gianluca
通讯作者：
Tosini, Gianluca
影响因子：
2
作者：
Serle, JB;Wang, RF;Yerxa, BR
通讯作者：
Yerxa, BR