Quantification of left atrial fibrosis by 3D late gadolinium-enhanced cardiac magnetic resonance imaging in patients with atrial fibrillation: impact of different analysis methods.
Quantification of left atrial fibrosis by 3D late gadolinium-enhanced cardiac magnetic resonance imaging in patients with atrial fibrillation: impact of different analysis methods.
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DOI：
10.1093/ehjci/jeab245
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发表时间：
2022-08-22
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已经开发了各种方法和后处理软件包来使用3D晚期钆增强心脏磁共振（LGE-CMR）图像量化左心房（LA）纤维化。目前尚不清楚这些方法和软件包的结果如何相互关联。47例房颤（AF）患者在AF消融前接受了3D-LGE-CMR成像。使用开源CEMRG软件和市售ADAS 3D-LA软件从图像中推导出LA纤维化负荷。两个软件包均用于基于图像强度比（IIR）方法计算纤维化。此外，使用高于平均血池信号强度的三个标准差（3SD），使用CEMRG定量LA纤维化。计算组内相关系数以比较LA纤维化定量方法和不同后处理软件输出。使用IIR阈值1.2评估的LA纤维化百分比与3SD方法显著不同（29.80 ± 14.15% vs. 8.43 ± 5.42%; P < 0.001）。IIR法和SD法之间的相关性良好（r = 0.85，P < 0.001），但一致性较差[组内相关系数（ICC）= 0.19; P < 0.001]。三分之一的患者被分配到不同的纤维化类别，这取决于所使用的定量方法。使用CEMRG和ADAS 3D-LA进行的纤维化评估显示IIR方法具有良好的一致性（ICC = 0.93; P < 0.001）。IIR1.2和3SD方法均基于心房壁信号强度差异量化心房纤维化负荷。当根据患者的纤维化负荷对患者进行分类时，这些方法之间的LA纤维化量差异可能具有临床意义。如果使用相同的定量方法（包括阈值），则用于定量LA纤维化的后处理软件包之间的结果无差异。
Various methods and post-processing software packages have been developed to quantify left atrial (LA) fibrosis using 3D late gadolinium-enhancement cardiac magnetic resonance (LGE-CMR) images. Currently, it remains unclear how the results of these methods and software packages interrelate. Forty-seven atrial fibrillation (AF) patients underwent 3D-LGE-CMR imaging prior to their AF ablation. LA fibrotic burden was derived from the images using open-source CEMRG software and commercially available ADAS 3D-LA software. Both packages were used to calculate fibrosis based on the image intensity ratio (IIR)-method. Additionally, CEMRG was used to quantify LA fibrosis using three standard deviations (3SD) above the mean blood pool signal intensity. Intraclass correlation coefficients were calculated to compare LA fibrosis quantification methods and different post-processing software outputs. The percentage of LA fibrosis assessed using IIR threshold 1.2 was significantly different from the 3SD-method (29.80 ± 14.15% vs. 8.43 ± 5.42%; P < 0.001). Correlation between the IIR-and SD-method was good (r = 0.85, P < 0.001) although agreement was poor [intraclass correlation coefficient (ICC) = 0.19; P < 0.001]. One-third of the patients were allocated to a different fibrosis category dependent on the used quantification method. Fibrosis assessment using CEMRG and ADAS 3D-LA showed good agreement for the IIR-method (ICC = 0.93; P < 0.001). Both, the IIR1.2 and 3SD-method quantify atrial fibrotic burden based on atrial wall signal intensity differences. The discrepancy in the amount of LA fibrosis between these methods may have clinical implications when patients are classified according to their fibrotic burden. There was no difference in results between post-processing software packages to quantify LA fibrosis if an identical quantification method including the threshold was used.
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影响因子：
4.6
作者：
Andreasen, Laura;Bertelsen, Litten;Olesen, Morten S.
通讯作者：
Olesen, Morten S.
影响因子：
2.7
作者：
Kamali, Roya;Schroeder, Joyce;DiBella, Edward;Steinberg, Benjamin;Han, Frederick;Dosdall, Derek J.;Macleod, Rob S.;Ranjan, Ravi
通讯作者：
Ranjan, Ravi
DOI：
10.1186/s12968-018-0449-8
发表时间：
2018-05-03
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Chubb H;Aziz S;Karim R;Sohns C;Razeghi O;Williams SE;Whitaker J;Harrison J;Chiribiri A;Schaeffter T;Wright M;O'Neill M;Razavi R
通讯作者：
Razavi R
DOI：
10.1007/s10554-019-01728-0
发表时间：
2020-03-01
影响因子：
2.1
作者：
Bertelsen, Litten;Alarcon, Francisco;Svendsen, Jesper Hastrup
通讯作者：
Svendsen, Jesper Hastrup
影响因子：
5.5
作者：
Malcolme-Lawes, L. C.;Juli, C.;Peters, N. S.
通讯作者：
Peters, N. S.