Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12.
Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12.
复制标题
NK 和 NKT 细胞对 IL-12 抗转移活性的相对贡献。
作者：
Kazuyoshi Takeda;Yoshihiro Hayakawa;M. Atsuta;Seokmann Hong;L. Kaer;Kimio Kobayashi;Mamoru Ito;H. Yagita;K. Okumura
Conventional T cells, NK cells and NKT cells have been implicated in the anti-tumor activities induced by IL-12. Here we show that IL-12-induced immune responses are partially impaired in T and NKT cell-deficient RAG-2(-/-) mice, and in NKT cell-deficient CD1(-/-) mice. In response to a small dose (<1000 U) of IL-12, RAG-2(-/-) and CD1(-/-) mice demonstrated reduced cytotoxicity, serum IFN-gamma elevation and anti-metastatic activities; in contrast, in response to a high dose (>2000 U) of IL-12, the IL-12-induced immune responses of RAG-2(-/-) and CD1(-/-) mice were indistinguishable from wild-type mice. The defective responses to low-dose IL-12 of RAG-2(-/-) mice were corrected by adoptive transfer of NKT cells but not NK cells. These findings indicate that both NK and NKT cells contribute to the anti-metastatic responses induced by IL-12, and that NKT cells are mostly responsible for the low-dose activities of this cytokine.
影响因子：
32.4
作者：
Mendiratta, SK;Martin, WD;VanKaer, L
通讯作者：
VanKaer, L
影响因子：
4.4
作者：
C. Tannenbaum;R. Tubbs;D. Armstrong;J. Finke;R. Bukowski;T. Hamilton
通讯作者：
C. Tannenbaum;R. Tubbs;D. Armstrong;J. Finke;R. Bukowski;T. Hamilton
影响因子：
32.4
作者：
Chen, YH;Chiu, NM;Wang, CR
通讯作者：
Wang, CR