Non-coding RNAs in lipid metabolism.
Non-coding RNAs in lipid metabolism.
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DOI：
10.1016/j.vph.2018.06.011
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发表时间：
2019-03
影响因子：
4
通讯作者：
Fernández-Hernando C
中科院分区：
文献类型：
--
作者：
Zhang X;Price NL;Fernández-Hernando C
心血管疾病（CVD）是西方世界死亡和发病的主要原因，其始于动脉壁中的脂质积聚，这是动脉粥样硬化形成的初始步骤。脂质代谢的改变导致心脏代谢紊乱的风险增加，脂质紊乱的治疗仍然是旨在降低CVD发病率的最常见策略。在过去十年中所做的工作已经确定了许多类别的非编码RNA分子，包括microRNA（miRNA）和长非编码RNA（lncRNA），作为参与脂质代谢和CVD的基因表达的关键调节因子，主要在转录后水平起作用。许多miRNAs（包括miR-33、miR-122和miR-148 a）已被证明通过调节胆固醇稳态和脂蛋白代谢在控制CVD风险中发挥重要作用。lncRNA是近年来发现的一种重要的脂质和脂蛋白代谢调节因子。然而，由于lncRNA的高丰度和物种之间的遗传保守性差，需要更多的工作来充分了解lncRNA对CVD和脂质代谢的影响。本文综述了miRNAs和lncRNAs在脂质和脂蛋白代谢中的作用及其对CVD治疗的潜在意义。
Cardiovascular disease (CVD), the leading cause of death and morbidity in the Western world, begins with lipid accumulation in the arterial wall, which is the initial step in atherogenesis. Alterations in lipid metabolism result in increased risk of cardiometabolic disorders, and treatment of lipid disorders remains the most common strategy aimed at reducing the incidence of CVD. Work done over the past decade has identified numerous classes of non-coding RNA molecules including microRNAs (miRNAs) and long-non-coding RNAs (lncRNAs) as critical regulators of gene expression involved in lipid metabolism and CVD, mostly acting at post-transcriptional level. A number of miRNAs, including miR-33, miR-122 and miR-148a, have been demonstrated to play important role in controlling the risk of CVD through regulation of cholesterol homeostasis and lipoprotein metabolism. lncRNAs are recently emerging as important regulators of lipid and lipoprotein metabolism. However, much additional work will be required to fully understand the impact of lncRNAs on CVD and lipid metabolism, due to the high abundance of lncRNAs and the poor-genetic conservation between species. This article reviews the role of miRNAs and lncRNAs in lipid and lipoprotein metabolism and their potential implications for the treatment of CVD.
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影响因子：
20.1
作者：
Allen RM;Marquart TJ;Jesse JJ;Baldán A
通讯作者：
Baldán A
影响因子：
4.3
作者：
Dikkers, Arne;Tietge, Uwe J. F.
通讯作者：
Tietge, Uwe J. F.
影响因子：
30.8
作者：
Bodzioch, M;Orsó, E;Schmitz, G
通讯作者：
Schmitz, G
DOI：
10.1161/atvbaha.112.300144
发表时间：
2013-02
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Fernández-Hernando C;Ramírez CM;Goedeke L;Suárez Y
通讯作者：
Suárez Y
影响因子：
29
作者：
Esau, C;Davis, S;Monia, BP
通讯作者：
Monia, BP