Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.
Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.
复制标题
DOI：
10.1126/science.1161550
复制
发表时间：
2008-10-17
期刊：
影响因子：
--
通讯作者：
Small DM
中科院分区：
文献类型：
--
作者：
Stice E;Spoor S;Bohon C;Small DM
背侧纹状体在消耗性食物奖励中起作用，并且相对于瘦个体，肥胖者的纹状体多巴胺受体减少，这表明纹状体和纹状体中的多巴胺能信号传导可能有助于肥胖的发展。因此，我们测试了食物摄入引起的纹状体激活是否与当前和未来的体重增加有关，以及这些关系是否受到TaqlA1基因A1等位基因的调节，该等位基因与纹状体多巴胺信号传导受损有关。两项功能性磁共振成像研究的横截面和前瞻性数据支持这些假设，表明个体可能会暴饮暴食，以弥补功能减退的背侧纹状体，特别是那些被认为减弱该区域多巴胺信号传导的遗传多态性。
The dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese relative to lean individuals, suggesting that the striatum and dopaminergic signaling in the striatum may contribute to development of obesity. Thus, we tested whether striatal activation in response to food intake is related to current and future increases in body mass and whether these relations are moderated by presence of the A1 allele of the TaqlA1 gene, which is associated with compromised striatal dopamine signaling. Cross-sectional and prospective data from two functional magnetic resonance imaging studies support these hypotheses, suggesting that individuals may overeat to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.
登录
查看更多内容
影响因子：
11
作者：
Jönsson, EG;Nöthen, MM;Sedvall, GC
通讯作者：
Sedvall, GC
影响因子：
14.5
作者：
Small, DM;Zatorre, RJ;Jones-Gotman, M
通讯作者：
Jones-Gotman, M
影响因子：
5.7
作者：
Tupala, E;Hall, H;Tiihonen, J
通讯作者：
Tiihonen, J
影响因子：
4.5
作者：
Spitz, MR;Detry, MA;Wu, XF
通讯作者：
Wu, XF
DOI：
10.1097/00008571-199608000-00003
发表时间：
1996-08-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Blum, K;Braverman, ER;Cull, JG
通讯作者：
Cull, JG