Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone
Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone
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大鼠腹腔中性粒细胞一氧化氮合酶的诱导及地塞米松的抑制
DOI：
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发表时间：
1991
影响因子：
5.4
通讯作者：
S. Moncada
中科院分区：
文献类型：
--
作者：
T. Mccall;R. Palmer;S. Moncada
牡蛎糖原诱导的大鼠腹膜多形核白细胞（PMN）含有一种钙非依赖性一氧化氮（NO）合酶，该酶在体内以时间依赖性方式诱导。当含有低水平酶活性的洗涤的PMN离体培养时，观察到NO合酶的进一步表达。这是抑制放线菌酮表明从头合成的酶发生在离体孵育。当离体加入时，干扰素（IFN）-γ增强了酶活性，但肿瘤坏死因子（TNF）-α则没有增强。然而，IFN-γ和TNF-α协同作用进一步增加NO合酶的表达。
Rat peritoneal polymorphonuclear leukocytes (PMN) elicited with oyster glycogen contain a Ca2+‐independent nitric oxide (NO) synthase which is induced in vivo in a time‐dependent manner. When washed PMN containing low levels of enzyme activity were cultured ex vivo further expression of NO synthase was observed. This was inhibited by cycloheximide indicating that de novo synthesis of the enzyme occurred during the ex vivo incubation. Enzyme activity was enhanced by interferon (IFN)‐γ, but not by tumor necrosis factor (TNF)‐α when added ex vivo. However, IFN‐γ and TNF‐α synergized to increase further the expression of NO synthase.
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影响因子：
4.4
作者：
D. Stuehr;M. Marletta
通讯作者：
D. Stuehr;M. Marletta
DOI：
10.1073/pnas.87.2.682
发表时间：
1990-01-01
影响因子：
11.1
作者：
BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH
缓激肽可增加培养的豚鼠气管平滑肌细胞中的 Na( )-K( ) 泵活性。
影响因子：
7.3
作者：
Dodson,AM;Rhoden,KJ
通讯作者：
Rhoden,KJ
DOI：
10.1016/s0006-291x(05)80086-5
发表时间：
1990-12-14
影响因子：
3.1
作者：
KIRK, SJ;REGAN, MC;BARBUL, A
通讯作者：
BARBUL, A