Effectiveness of Postoperative Adjuvant Radiotherapy in Atypical Meningioma Patients After Gross Total Resection: A Meta-Analysis Study.
Effectiveness of Postoperative Adjuvant Radiotherapy in Atypical Meningioma Patients After Gross Total Resection: A Meta-Analysis Study.
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肉眼全切除后非典型脑膜瘤患者术后辅助放疗的有效性：一项荟萃分析研究
DOI：
10.3389/fonc.2020.556575
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发表时间：
2020
影响因子：
4.7
通讯作者：
Zeng Q
中科院分区：
文献类型：
--
作者：
He L;Zhang B;Zhang J;Guo Z;Shi F;Zeng Q
背景：目前还不清楚非典型脑膜瘤（AM）患者在全切除术（GTR）后是否能从术后辅助放疗（PORT）中获益。目的探讨经尿道前列腺电切术（GTR）后应用PORT治疗AM的疗效。方法检索PubMed、Embase、Web of science和Scopus数据库2000年1月至2019年1月期间发表的文献。根据排除标准进行筛选后，采用Newcastle-Ottawa评价量表对纳入文献进行质量评价。最后进行荟萃分析，分析PORT对GTR后非典型脑膜瘤患者的局部控制（LC）、无进展生存期（PFS）和总生存期（OS）的有效性。结果共纳入17篇文献，2,008例AM患者。GTR后接受PORT的AM患者的5年LC、5年PFS和5年OS率分别为82.2%、84.1%和79.0%，GTR后未接受PORT的AM患者的5年LC、5年PFS和5年OS率分别为71.0%、71.9%和81.5%。PORT可显著提高5年LC率（OR [95% CI] = 2.59 [1.40-4.81]，P = 0.002）和5年PFS率（OR [95% CI] = 1.99 [1.35-2.95]，P = 0.001），但未显著提高5年OS率（OR [95% CI] = 1.07 [0.60-1.91]，P = 0.828）。结论PORT可提高AM患者GTR后的5年LC率和5年PFS率。AM患者在GTR后可能受益于PORT。
Background It still remains unclear whether patients with atypical meningioma (AM) could benefit from postoperative adjuvant radiotherapy (PORT) after gross-total resection (GTR). Objective Exploring the effectiveness of PORT on AM patients after GTR. Methods Literatures on PubMed, Embase, Web of science, and Scopus databases published between January 2000 and January 2019 were searched. After the selection based on the certain exclusion criteria, the Newcastle-Ottawa evaluation scale was used to evaluate the quality of the included literatures. Finally, a meta-analysis was conducted to analyze the effectiveness of PORT on local control (LC), progression-free survival (PFS) and overall survival (OS) in atypical meningioma patients after GTR. Results A total of 17 articles with 2,008 AM patients were included in the meta-analysis. The 5-year LC, 5-year PFS, and 5-year OS rates were 82.2, 84.1, and 79.0%, respectively, for AM patients receiving PORT after GTR, and they were 71.0, 71.9, and 81.5%, respectively, for those not receiving PORT after GTR. PORT could significantly improve 5-year LC rate (OR [95% Cl] = 2.59 [1.40–4.81], P = 0.002) and 5-year PFS rate (OR [95% Cl] = 1.99 [1.35–2.95], P = 0.001), but did not significantly improve 5-year OS rate (OR [95% Cl] = 1.07 [0.60–1.91], P = 0.828). Conclusion PORT could improve the 5-year LC rate and 5-year PFS rate in AM patients after GTR. AM patients might benefit from PORT after GTR.
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影响因子：
4.1
作者：
Rogers L;Barani I;Chamberlain M;Kaley TJ;McDermott M;Raizer J;Schiff D;Weber DC;Wen PY;Vogelbaum MA
通讯作者：
Vogelbaum MA
影响因子：
4.1
作者：
Bagshaw, Hilary P.;Burt, Lindsay M.;Shrieve, Dennis C.
通讯作者：
Shrieve, Dennis C.
影响因子：
4.1
作者：
Shakir, Shakir I.;Souhami, Luis;Guiot, Marie-Christine
通讯作者：
Guiot, Marie-Christine
影响因子：
1.9
作者：
Wang, Yu-Chi;Chuang, Chi-Cheng;Chen, Pin-Yuan
通讯作者：
Chen, Pin-Yuan
影响因子：
3.9
作者：
Park, Hae Jin;Kang, Hyun-Cheol;Jung, Hee-Won
通讯作者：
Jung, Hee-Won