Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting.
Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting.
复制标题
DOI：
10.1371/journal.pgen.1010019
复制
发表时间：
2022-03
期刊：
影响因子：
4.5
通讯作者：
Grijalva MJ
中科院分区：
文献类型：
--
作者：
Hernandez-Castro LE;Villacís AG;Jacobs A;Cheaib B;Day CC;Ocaña-Mayorga S;Yumiseva CA;Bacigalupo A;Andersson B;Matthews L;Landguth EL;Costales JA;Llewellyn MS;Grijalva MJ
准确预测病媒的扩散，以及查明使吸血病媒在人造环境中茁壮成长的适应性，是有效控制疾病的基础。在这里，我们采用了景观基因组学的方法来分析基因流，可能的本地适应，和种群结构的驱动因素，在厄瓜多尔红锥虫病的重要载体。我们使用简化代表性测序技术（2b-RADseq）在272个R中获得2，552个SNP标记。厄瓜多尔南部25个采集点采集的样本。在我们的研究地点，7个野生和国内人口对之间的高和定向基因流的证据表明，基于杂草的控制将受到来自森林的房屋的重复再侵染的阻碍。对多个群体对的初步基因组扫描显示，共享的离群位点可能与当地对家庭环境的适应一致，我们将其映射到与胚胎发生和唾液产生有关的基因。景观基因组模型表明海拔是R.厄瓜多尔散布总之，我们的研究结果揭示了锥蝽载体的基因组适应的早期光，并通过预测空间靶向的主动干预将比目前的反应性方法更有效来促进载体控制。野生/次生锥蝽再次侵扰最近经过消毒处理的房屋，它们对这种新环境的潜在适应能力以及在多个人类社区中地理分布的能力，危及可持续的恰加斯病控制。这是查加斯病媒介的第一项研究，确定了可能与适应建筑环境有关的基因组区域，并描述了准确预测地理分布的景观驱动因素。我们在厄瓜多尔南部的山区采集了多个国内和野生Rhodnius ecuadoriensis种群对。我们证明了锥蝽从森林到建筑环境的迁移率很高。在这些高度连接的群体对中，我们检测到可能与我们评估的基因组标记之间的局部适应相关的基因座，并为未来的锥蝽基因组研究铺平了道路。我们强调，目前在该地区的随意病媒控制将受到来自森林的锥蝽再侵染的阻碍。相反，我们建议频繁和空间有针对性的载体控制，并提供了一个landacape基因组模型，识别高度连接和隔离锥蝽种群，以促进有效的载体控制。
Accurate prediction of vectors dispersal, as well as identification of adaptations that allow blood-feeding vectors to thrive in built environments, are a basis for effective disease control. Here we adopted a landscape genomics approach to assay gene flow, possible local adaptation, and drivers of population structure in Rhodnius ecuadoriensis, an important vector of Chagas disease. We used a reduced-representation sequencing technique (2b-RADseq) to obtain 2,552 SNP markers across 272 R. ecuadoriensis samples from 25 collection sites in southern Ecuador. Evidence of high and directional gene flow between seven wild and domestic population pairs across our study site indicates insecticide-based control will be hindered by repeated re-infestation of houses from the forest. Preliminary genome scans across multiple population pairs revealed shared outlier loci potentially consistent with local adaptation to the domestic setting, which we mapped to genes involved with embryogenesis and saliva production. Landscape genomic models showed elevation is a key barrier to R. ecuadoriensis dispersal. Together our results shed early light on the genomic adaptation in triatomine vectors and facilitate vector control by predicting that spatially-targeted, proactive interventions would be more efficacious than current, reactive approaches. Re-infestation of recently insecticide-treated houses by wild/secondary triatomine, their potential adaptation to this new environment and capabilities to geographically disperse across multiple human communities jeopardise sustainable Chagas disease control. This is the first study in Chagas disease vectors that identifies genomic regions possibly linked to adaptations to the built environment and describes landscape drivers for accurate prediction of geographic dispersal. We sampled multiple domestic and wild Rhodnius ecuadoriensis population pairs across a mountainous terrain in southern Ecuador. We evidenced that triatomine movement from forest to built enviroments does occur at a high rate. In these highly connected population pairs we detected loci possibly linked to local adaptation among the genomic makers we evaluated and in doing so we pave the way for future triatomine genomic research. We highlighted that current haphazardous vector control in the zone will be hindered by reinfestation of triatomines from the forest. Instead, we recommend frequent and spatially-targeted vector control and provided a landacape genomic model that identifies highly connected and isolated triatomine populations to facilitate efficient vector control.
登录
查看更多内容
人类的影响塑造了埃及埃及，登革热和黄热病蚊子的历史和最新进化。
DOI：
10.1111/evo.12281
发表时间：
2014-02
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Brown JE;Evans BR;Zheng W;Obas V;Barrera-Martinez L;Egizi A;Zhao H;Caccone A;Powell JR
通讯作者：
Powell JR
影响因子：
2.8
作者：
Dujardin, JP;Steindel, M;Schofield, CJ
通讯作者：
Schofield, CJ
DOI：
10.1198/108571102320
发表时间：
2002-09-01
影响因子：
1.4
作者：
Clarke, RT;Rothery, P;Raybould, AF
通讯作者：
Raybould, AF
影响因子：
5.8
作者：
Bradbury, Peter J.;Zhang, Zhiwu;Buckler, Edward S.
通讯作者：
Buckler, Edward S.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y