Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina.
Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina.
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DOI：
10.1002/dneu.20880
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发表时间：
2012-04
影响因子：
3
通讯作者：
Cline, Hollis T.
中科院分区：
文献类型：
--
作者：
Demas, James A.;Payne, Hannah;Cline, Hollis T.
发育中的两栖动物在视觉系统电路完全成熟之前需要视觉来躲避捕食者和定位食物。非洲爪蟾蝌蚪只要视网膜神经节细胞（RGCs）支配大脑就可以对视觉刺激做出反应，然而，在哺乳动物、小鸡和海龟中，RGCs在视网膜能够视觉之前许多天甚至几周就到达了它们的中心目标。在没有视觉的情况下，这些灵长类动物的活动依赖性细化是由自发活动波介导的，这些自发活动波周期性地在视网膜上传播，与相邻RGC中的动作电位放电相关。理论表明，大脑中的视网膜接受神经元使用模式化的RGC活动来增强最初由遗传线索建立的视网膜反应。我们发现，在野生型和白化病爪蟾蝌蚪，RGCs是自发活跃的蝌蚪发育研究的各个阶段，但他们的人口活动从来没有合并成波。即使在记录的最早阶段，视觉刺激也比自发活动占主导地位，并且可以产生类似于在羊水中观察到的局部相关自发活动的RGC活动模式。此外，我们表明，阻断AMPA和NMDA型谷氨酸受体显着降低自发活动在年轻的非洲爪蟾视网膜，但GABAA受体阻滞剂的阻断剂没有。我们的研究结果表明，视觉驱动器地形图形成所需的相关活动。他们进一步表明，在四足动物的两个主要亚类（两栖动物和两栖动物）中发育视网膜回路，进化出不同的策略来提供适当模式的RGC活动，以驱动视觉回路的完善。
Developing amphibians need vision to avoid predators and locate food before visual system circuits fully mature. Xenopus tadpoles can respond to visual stimuli as soon as retinal ganglion cells (RGCs) innervate the brain, however, in mammals, chicks and turtles, RGCs reach their central targets many days, or even weeks, before their retinas are capable of vision. In the absence of vision, activity-dependent refinement in these amniote species is mediated by waves of spontaneous activity that periodically spread across the retina, correlating the firing of action potentials in neighboring RGCs. Theory suggests that retinorecipient neurons in the brain use patterned RGC activity to sharpen the retinotopy first established by genetic cues. We find that in both wild type and albino Xenopus tadpoles, RGCs are spontaneously active at all stages of tadpole development studied, but their population activity never coalesces into waves. Even at the earliest stages recorded, visual stimulation dominates over spontaneous activity and can generate patterns of RGC activity similar to the locally correlated spontaneous activity observed in amniotes. In addition, we show that blocking AMPA and NMDA type glutamate receptors significantly decreases spontaneous activity in young Xenopus retina, but that blocking GABAA receptor blockers does not. Our findings indicate that vision drives correlated activity required for topographic map formation. They further suggest that developing retinal circuits in the two major subdivisions of tetrapods, amphibians and amniotes, evolved different strategies to supply appropriately patterned RGC activity to drive visual circuit refinement.
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影响因子：
16.2
作者：
Li, Jianli;Erisir, Alev;Cline, Hollis
通讯作者：
Cline, Hollis
影响因子：
2.5
作者：
Dong, Wei;Lee, Ryan H.;Aizenman, Carlos D.
通讯作者：
Aizenman, Carlos D.
影响因子：
2.5
作者：
Aizenman, Carlos D.;Cline, Hollis T.
通讯作者：
Cline, Hollis T.
影响因子：
5.3
作者：
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通讯作者：
Cline, HT
影响因子：
5.3
作者：
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通讯作者：
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