Stem cells engineering for cell-based therapy
Stem cells engineering for cell-based therapy
复制标题
用于细胞治疗的干细胞工程
DOI：
--
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发表时间：
2007
影响因子：
4
通讯作者：
P. Taupin
中科院分区：
文献类型：
--
作者：
P. Taupin
干细胞有望治愈多种疾病和损伤，从糖尿病、心脏和肌肉疾病，到神经系统疾病、失调和损伤。在过去的十年中，干细胞研究取得了重大进展；从人体组织中提取胚胎干细胞（ESCs），通过体细胞核移植（SCNT）克隆技术的发展，以及证实神经发生发生在成年哺乳动物的大脑中，神经干细胞（NSCs）存在于成人中枢神经系统（包括人类中枢神经系统）中。尽管取得了这些进展，但干细胞研究要转化为治疗可能还有几十年的时间。干细胞研究还受到伦理和政治辩论、争议和立法的影响，这减慢了其进展。细胞工程已被证明成功地将基因研究引入了治疗领域。在这篇综述中，我将通过两个例子来回顾研究人员如何将细胞工程应用于干细胞生物学，以规避干细胞的伦理和政治限制，并支持干细胞研究和治疗。
Stem cells carry the promise to cure a broad range of diseases and injuries, from diabetes, heart and muscular diseases, to neurological diseases, disorders and injuries. Significant progresses have been made in stem cell research over the past decade; the derivation of embryonic stem cells (ESCs) from human tissues, the development of cloning technology by somatic cell nuclear transfer (SCNT) and the confirmation that neurogenesis occurs in the adult mammalian brain and that neural stem cells (NSCs) reside in the adult central nervous system (CNS), including that of humans. Despite these advances, there may be decades before stem cell research will translate into therapy. Stem cell research is also subject to ethical and political debates, controversies and legislation, which slow its progress. Cell engineering has proven successful in bringing genetic research to therapy. In this review, I will review, in two examples, how investigators are applying cell engineering to stem cell biology to circumvent stem cells' ethical and political constraints and bolster stem cell research and therapy.
DOI：
10.1073/pnas.97.23.12846
发表时间：
2000-11-07
影响因子：
11.1
作者：
Aboody, KS;Brown, A;Snyder, EY
通讯作者：
Snyder, EY
影响因子：
56.9
作者：
GAGE, FH;BJORKLUND, A;KELLY, PAT
通讯作者：
KELLY, PAT
影响因子：
158.5
作者：
Freed, CR;Greene, PE;Fahn, S
通讯作者：
Fahn, S