Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin.
Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin.
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膳食类黄酮 Didymin 潜在治疗应用的最新趋势
DOI：
10.3390/molecules23102547
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发表时间：
2018-10-06
期刊：
影响因子：
--
通讯作者：
Zhao YZ
中科院分区：
文献类型：
--
作者：
Yao Q;Lin MT;Zhu YD;Xu HL;Zhao YZ
Didymin（isosakuranetin 7-O-rutinoside）是一种口服生物活性膳食黄酮苷，首先在柑橘类水果中发现。传统上，这种黄酮类化合物长期以来在亚洲国家被用作膳食抗氧化剂。最近的研究为这种多效性化合物提供了新的见解，它可以调节健康和疾病中许多重要信号分子的多种生物活性。新数据还展示了膳食类黄酮苷双联明对癌症、神经系统疾病、肝脏疾病、心血管疾病和其他疾病的潜在治疗应用。在这篇综述中，我们简要介绍了didymin的来源和提取方法，并总结了其在治疗各种疾病中的潜在治疗应用，重点介绍了有助于观察到的治疗效果的分子靶点和机制。膳食类黄酮双地明可通过多个治疗靶点影响健康和疾病，预计本次综述将刺激这种潜在膳食药物的未来发展。
Didymin (isosakuranetin 7-O-rutinoside) is an orally bioactive dietary flavonoid glycoside first found in citrus fruits. Traditionally, this flavonoid has long been used in Asian countries as a dietary antioxidant. Recent studies have provided newer insights into this pleiotropic compound, which could regulate multiple biological activities of many important signaling molecules in health and disease. Emerging data also presented the potential therapeutic application of dietary flavonoid glycoside didymin against cancer, neurological diseases, liver diseases, cardiovascular diseases, and other diseases. In this review, we briefly introduce the source and extraction methods of didymin, and summarize its potential therapeutic application in the treatment of various diseases, with an emphasis on molecular targets and mechanism that contributes to the observed therapeutic effects. The dietary flavonoid didymin can be used to affect health and disease with multiple therapeutic targets, and it is anticipated that this review will stimulate the future development of this potential dietary medicine.
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影响因子：
3.1
作者：
Dugo, P;Lo Presti, M;Mondello, L
通讯作者：
Mondello, L
影响因子：
5.6
作者：
Androutsopoulos, Vasilis P.;Spandidos, Demetrios A.
通讯作者：
Spandidos, Demetrios A.
影响因子：
8.8
作者：
Di Donna, Leonardo;Taverna, Domenico;Sindona, Giovanni
通讯作者：
Sindona, Giovanni
影响因子：
3.5
作者：
Bakshi, Rachit;Xu, Yuehang;Schwarzschild, Michael A.
通讯作者：
Schwarzschild, Michael A.
DOI：
10.3390/molecules23061247
发表时间：
2018-05-23
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Cudalbeanu M;Ghinea IO;Furdui B;Dah-Nouvlessounon D;Raclea R;Costache T;Cucolea IE;Urlan F;Dinica RM
通讯作者：
Dinica RM