Long non-coding RNA HOTAIR polymorphism and susceptibility to cancer: an updated meta-analysis.
Long non-coding RNA HOTAIR polymorphism and susceptibility to cancer: an updated meta-analysis.
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DOI：
10.1186/s12199-018-0697-0
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发表时间：
2018-02-20
影响因子：
4.7
通讯作者：
Yin Z
中科院分区：
文献类型：
--
作者：
Li J;Cui Z;Li H;Lv X;Gao M;Yang Z;Bi Y;Zhou B;Yin Z
越来越多的出版物引起了人们对HOX转录反义RNA（HOTAIR）中六种常见多态性与癌症风险之间的关联的关注，而这些结果一直存在争议和不一致。我们进行了一项最新的荟萃分析，以汇集符合条件的研究，并进一步探讨HOTAIR多态性（rs 920778，rs7958904，rs 12826786，4，759，314，rs 874945和rs 1899663）与癌症风险之间的可能关系。截至2017年7月1日，在PubMed、Web of Science和CNKI数据库中进行了系统检索。纳入18篇符合条件的文献，包括45项病例对照研究，共58，601例受试者，以评估HOTAIR的6种多态性与癌症风险之间的关系。分析合并优势比（OR）和95%置信区间（CI），以揭示多态性和癌症易感性。所有统计学分析均采用STATA 11.0软件进行。合并分析发现rs 920778多态性与隐性、显性、等位基因、纯合子和杂合子模型中癌症易感性增加之间存在显著相关性。对于rs7958904多态性，我们获得的多态性显着降低了5个遗传模型，而不是隐性和纯合子模型的整体癌症风险的易感性。对于rs 12826786多态性，我们发现它在所有遗传模型而不是杂合子模型中显著增加了癌症风险的易感性。然而，未发现rs 1899663、rs 874945和rs 4759314多态性与癌症易感性之间存在显著关联。这些荟萃分析的结果表明，HOTAIR基因多态性可能有助于癌症的易感性。本文的在线版本（10.1186/s12199-018-0697-0）包含补充材料，可供授权用户使用。
An increasing number of publications are drawing attention to the associations between six common polymorphisms in HOX transcript anti-sense RNA (HOTAIR) and the risk of cancers, while these results have been controversial and inconsistent. We conducted an up-to-date meta-analysis to pool eligible studies and to further explore the possible relationships between HOTAIR polymorphisms (rs920778, rs7958904, rs12826786, 4,759,314, rs874945, and rs1899663) and cancer risk. A systematic retrieval was conducted up to 1 July 2017 in the PubMed, Web of Science, and CNKI databases. Eighteen eligible publications including 45 case-control studies with 58,601subjects were enrolled for assessing the associations between the 6 polymorphisms in HOTAIR and cancer risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed to reveal the polymorphisms and susceptibility to cancer. All the statistical analyses were performed using STATA 11.0 software. The pooled analyses detected significant associations between the rs920778 polymorphism and increased susceptibility to cancer in recessive, dominant, allelic, homozygous, and heterozygous models. For the rs7958904 polymorphism, we obtained the polymorphism significantly decreased susceptibility to overall cancer risk among five genetic models rather than recessive and homozygous models. For the rs12826786 polymorphism, we identified it significantly increased susceptibility to cancer risk in all genetic models rather than heterozygous models. However, no significant association was found between the rs1899663, rs874945, and rs4759314 polymorphisms and susceptibility of cancer. These findings of the meta-analysis suggest that HOTAIR polymorphism may contribute to cancer susceptibility. The online version of this article (10.1186/s12199-018-0697-0) contains supplementary material, which is available to authorized users.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Gong, Wei-Jing;Yin, Ji-Ye;Liu, Zhao-Qian
通讯作者：
Liu, Zhao-Qian
DOI：
10.1016/j.bbcan.2015.07.001
发表时间：
2015-08
期刊：
Biochimica et biophysica acta
影响因子：
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作者：
Bhan A;Mandal SS
通讯作者：
Mandal SS
长非编码 RNA HOTAIR 是恶性肿瘤的驱动因素，可预测食管鳞状细胞癌的阴性预后并表现出致癌活性
影响因子：
8.8
作者：
Li, X.;Wu, Z.;Mei, Q.;Li, X.;Guo, M.;Fu, X.;Han, W.
通讯作者：
Han, W.
影响因子：
3.7
作者：
Guo L;Lu X;Zheng L;Liu X;Hu M
通讯作者：
Hu M