The Influence of HLA Alleles on the Affective Distress Profile.
The Influence of HLA Alleles on the Affective Distress Profile.
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DOI：
10.3390/ijerph191912608
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发表时间：
2022-10-02
影响因子：
--
通讯作者：
Siserman, Costel Vasile
中科院分区：
文献类型：
--
作者：
Vica, Mihaela Laura;Delcea, Cristian;Dumitrel, Gabriela Alina;Vuscan, Mihaela Elvira;Matei, Horea Vladi;Teodoru, Cosmin Adrian;Siserman, Costel Vasile
(1)背景：攻击性刺激可引发情感困扰，对个体有不利作用。导致精神障碍发展和进化的一些因素可能是遗传的。本研究的目的是确定人类白细胞抗原(HLA)基因与情感苦恼特征(PDA)之间的一些相关性。(2)采用焦虑心理测评工具对115名受试者进行测试。从血液中提取DNA后，用聚合酶链式反应技术鉴定低分辨的人类白细胞抗原I类(HLA-A、B、C)和II类(人类白细胞抗原DRB1、人类白细胞抗原DQB1)等位基因。根据PDA，受试者被分为两组：一组为低PDA组，另一组为中、高PDA组。用IBM SPSS软件比较两组间的等位基因频率。(3)单因素分析显示，低PDA组与HLA-A(A*01、A*30)、HLA-B(B*08)、HLA-DRB1(DRB1*11)等位基因有显著关联，与中、高PDA组有显著关联(A*32、B*52、C*12)。(4)结论：本研究强调了人类白细胞抗原等位基因与焦虑症的潜在关联。
(1) Background: Affective distress can be triggered by aggressive stimuli with an unfavorable role for the individual. Some of the factors that lead to the development and evolution of a mental disorder can be genetic. The aim of this study is to determine some correlations between the human leukocyte antigen (HLA) genes and the affective distress profile (PDA). (2) Methods: A psychological assessment and testing tool for anxiety was applied to 115 people. The low-resolution HLA alleles of class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1 and HLA-DQB1) were identified by the PCR technique after DNA extraction from the blood. Depending on the PDA, the subjects were divided into two groups: a group with a low PDA and another one with a medium and high PDA. The IBM SPSS software was used to compare the frequency of HLA alleles between the two groups. (3) Results: The univariate analysis revealed a significant association of the HLA-A locus (A*01, A*30), HLA-B (B*08), and HLA-DRB1 (DRB1*11) with the low PDA group and of the HLA-A locus (A*32), HLA-B (B*52), and HLA-C (C*12) with the medium and high PDA group. (4) Conclusions: The present study highlighted potential associations between HLA alleles and anxiety disorders.
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影响因子：
14.2
作者：
Du, Rose;Litonjua, Augusto A.;Weiss, Scott T.
通讯作者：
Weiss, Scott T.
多发性硬化症和精神分裂症之间的遗传多效性，但不是躁郁症：免疫相关基因基因座的差异参与。
影响因子：
11
作者：
Andreassen, O. A.;Harbo, H. F.;Wang, Y.;Thompson, W. K.;Schork, A. J.;Mattingsdal, M.;Zuber, V.;Bettella, F.;Ripke, S.;Kelsoe, J. R.;Kendler, K. S.;O'Donovan, M. C.;Sklar, P.;McEvoy, L. K.;Desikan, R. S.;Lie, B. A.;Djurovic, S.;Dale, A. M.
通讯作者：
Dale, A. M.
DOI：
10.1111/j.1601-183x.2010.00619.x
发表时间：
2010-10
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Middeldorp CM;Slof-Op 't Landt MC;Medland SE;van Beijsterveldt CE;Bartels M;Willemsen G;Hottenga JJ;de Geus EJ;Suchiman HE;Dolan CV;Neale MC;Slagboom PE;Boomsma DI
通讯作者：
Boomsma DI
影响因子：
6.7
作者：
Arias, B.;Aguilera, M.;Fananas, L.
通讯作者：
Fananas, L.
影响因子：
3.5
作者：
Ivanov, Roman;Zamyatin, Vladimir;Lashin, Sergey
通讯作者：
Lashin, Sergey