TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14).
TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14).
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DOI：
10.1016/j.coi.2011.08.008
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发表时间：
2011-10
影响因子：
7
通讯作者：
Sedý JR
中科院分区：
文献类型：
--
作者：
Ware CF;Sedý JR
The herpesvirus entry mediator (HVEM; TNFRSF14) can activate either proinflammatory or inhibitory signaling pathways. HVEM engages two distinct types of ligands, the canonical TNF-related cytokines, LIGHT and Lymphotoxin-α, and the Ig-related membrane proteins, BTLA (B and T lymphocyte attenuator) and CD160. Recent evidence indicates that the signal generated by HVEM depends on the context of its ligands expressed in trans or in cis. HVEM engagement by all of its ligands in trans initiates bidirectional signaling. In contrast, naïve T cells coexpress BTLA and HVEM forming a cis-complex that interferes with the activation of HVEM by extraneous ligands in the surrounding microenvironment. The HVEM network is emerging as a key survival system for effector and memory T cells in mucosal tissues.
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影响因子：
2.8
作者：
del Rio, Maria-Luisa;Kaye, Jonathan;Rodriguez-Barbosa, Jose-Ignacio
通讯作者：
Rodriguez-Barbosa, Jose-Ignacio
DOI：
10.4049/jimmunol.0902490
发表时间：
2009-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cheung TC;Oborne LM;Steinberg MW;Macauley MG;Fukuyama S;Sanjo H;D'Souza C;Norris PS;Pfeffer K;Murphy KM;Kronenberg M;Spear PG;Ware CF
通讯作者：
Ware CF
DOI：
10.1073/pnas.0902115106
发表时间：
2009-04-14
影响因子：
11.1
作者：
Cheung, Timothy C.;Steinberg, Marcos W.;Ware, Carl F.
通讯作者：
Ware, Carl F.
影响因子：
32.4
作者：
Kabashima, K;Banks, TA;Cyster, JG
通讯作者：
Cyster, JG
影响因子：
16
作者：
Carfí, A;Willis, SH;Wiley, DC
通讯作者：
Wiley, DC