The Treatment Outcomes of Olfactory Neuroblastoma Patients With Frontal Lobe Invasion.
The Treatment Outcomes of Olfactory Neuroblastoma Patients With Frontal Lobe Invasion.
复制标题
侵犯额叶的嗅神经母细胞瘤患者的治疗效果
DOI：
10.3389/fonc.2021.640892
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Song X
中科院分区：
文献类型：
--
作者：
Wang J;Wang L;He H;Li Y;Song X
背景 探讨额叶侵犯（FLI）是否是嗅神经母细胞瘤（ONB）患者的不良预后因素，并探讨伴有 FLI 的 ONB 患者的最佳治疗策略。方法对37例FLI患者进行回顾性研究，并选取74例匹配的无FLI患者作为对照组。比较两组之间的长期生存率。结果 两组患者的总生存期（OS）、无进展生存期（PFS）、局部无失败生存期（LRFS）和无远处转移生存期（DMFS）均无显着差异（均p>0.05）。多变量分析表明，FLI 并不是 OS 的独立预测因子（HR = 1.100，95% CI = 0.437–2.772，p = 0.840）。在 37 名 FLI 患者中，与未接受手术的患者相比，接受手术联合化疗/放疗的患者显示出更好的 OS（89.4% vs. 53.6%，p = 0.001）和 PFS（87.8% vs. 53.6%，p = 0.001）。结论 FLI 并不是 ONB 患者的不良预后因素。内镜下切除联合放疗是治疗FLI ONB患者的有效方法。
Background To investigate whether frontal lobe invasion (FLI) was an unfavorable prognostic factor in patients with olfactory neuroblastoma (ONB), and to explore the optimal treatment strategy for ONB patients with FLI. Methods Some 37 patients with FLI were retrospectively studied, and 74 well-matched patients without FLI were enrolled as the control group. The long-term survivals were compared between the two groups. Results No significant differences were found between the two groups in overall survival (OS), progression-free survival (PFS), locoregional failure-free survival (LRFS), and distant metastasis-free survival (DMFS) (all p >0.05). Multivariate analyses showed that FLI wasn’t an independent predictor for OS (HR = 1.100, 95% CI = 0.437–2.772, p = 0.840). Among the 37 patients with FLI, patients who received surgery combined with chemo-/radiotherapy showed better OS (89.4% vs. 53.6%, p = 0.001) and PFS (87.8% vs. 53.6%, p = 0.001) compared with those who didn’t undergo surgery. Conclusions FLI wasn’t a poor prognostic factor for ONB patients. Endoscopic resection combined with radiotherapy was an effective therapeutic method for ONB patients with FLI.
登录
查看更多内容
DOI：
10.1016/0360-3016(93)90457-7
发表时间：
1993-11-15
影响因子：
7
作者：
FOOTE, RL;MORITA, A;OFALLON, WM
通讯作者：
OFALLON, WM
DOI：
10.1002/hed.24912
发表时间：
2017-12-01
影响因子：
2.9
作者：
Harvey, Richard J.;Nalavenkata, Sunny;Gallagher, Richard
通讯作者：
Gallagher, Richard
影响因子：
3.9
作者：
Rock, Andrew K.;Dincer, Alper;Broaddus, William C.
通讯作者：
Broaddus, William C.
DOI：
10.1016/j.ijrobp.2009.09.019
发表时间：
2010-11-15
影响因子：
7
作者：
Ozsahin, Mahmut;Gruber, Guenther;Zouhair, Abderrahim
通讯作者：
Zouhair, Abderrahim
影响因子：
3.9
作者：
Villano JL;Bressler L;Propp JM;Valyi-Nagy T;Martin IK;Dolecek TA;McCarthy BJ
通讯作者：
McCarthy BJ