A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.
A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.
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酪氨酸激酶家族的一个可能的新成员，人类frt序列，在脊椎动物中高度保守，位于人类13号染色体上。
DOI：
10.20772/cancersci1985.78.7_655
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Shibuya
中科院分区：
文献类型：
--
作者：
H. Matsushime;M. Yoshida;M. Sasaki;M. Shibuya
我们分离到一个人基因组DNA（命名为人frt），它与UR 2肉瘤病毒的v-ros癌基因交叉杂交。对该片段的测序分析表明，该序列包含一个123个碱基对的外显子样结构，周围是剪接受体和供体位点的共有序列。推导的氨基酸序列与src家族酪氨酸激酶结构域的一部分高度同源。人类的frt序列在许多脊椎动物中是保守的。通过使用人-小鼠杂交瘤板，人frt位于13号染色体上，而人c-ros-1位于6号染色体上。
We have isolated a human genomic DNA (designated human frt) cross-hybridizing with the v-ros oncogene of UR2 sarcoma virus. Sequencing analysis of this fragment revealed that this sequence contains a 123-base-pair exon-like structure surrounded by consensus sequences of splice acceptor and donor sites. The deduced amino acid sequence of this stretch was highly homologous to a portion of a tyrosine kinase domain of src family. The human frt sequence was found to be conserved in a wide variety of vertebrates. By using a human-mouse hybridoma panel, human frt was located on chromosome 13, while human c-ros-1 was located on chromosome 6.
DOI：
10.1073/pnas.83.17.6568
发表时间：
1986-09-01
影响因子：
11.1
作者：
NAGARAJAN, L;LOUIE, E;CROCE, CM
通讯作者：
CROCE, CM