Connexins in vascular physiology and pathology.
Connexins in vascular physiology and pathology.
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DOI：
10.1089/ars.2008.2115
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发表时间：
2009-02
影响因子：
6.6
通讯作者：
Kwak BR
中科院分区：
文献类型：
--
作者：
Brisset AC;Isakson BE;Kwak BR
血管中的细胞相互作用通过多种通信途径维持，包括间隙连接。它们由细胞间通道组成，确保内皮细胞和平滑肌细胞之间的直接相互作用以及它们沿着血管壁的行为的同步化。间隙连接通道由两个半通道或连接子的对接产生，通过六个连接蛋白的组装形成，并通过允许两个相邻细胞之间的小代谢物、第二信使和离子的运输来实现直接的细胞通信。沿血管树沿着观察到连接蛋白表达的生理变化，最常见的连接蛋白是Cx37、Cx40和Cx43。连接蛋白表达水平的变化与血管疾病如高血压、动脉粥样硬化或再狭窄的发展相关。最近对连接蛋白缺陷小鼠的研究强调了这些通信途径在这些病理学发展中的关键作用，并敦促需要有针对性的药理学方法来预防和治疗。本文就缝隙连接在血管功能和常见心血管疾病中的作用作一综述。
Cellular interaction in blood vessels is maintained by multiple communication pathways, including gap junctions. They consist of intercellular channels ensuring direct interaction between endothelial and smooth muscle cells and the synchronization of their behavior along the vascular wall. Gap junction channels arise from the docking of two hemichannels or connexons, formed by the assembly of six connexins, and achieve direct cellular communication by allowing the transport of small metabolites, second messengers and ions between two adjacent cells. Physiological variations in connexin expression are observed along the vascular tree, with most common connexins being Cx37, Cx40 and Cx43. Changes in the level of expression of connexins have been correlated to the development of vascular disease, such as hypertension, atherosclerosis or restenosis. Recent studies on connexin-deficient mice highlighted key roles of these communication pathways in the development of these pathologies, and urged the need for targeted pharmacological approaches for their prevention and treatment. The aim of this issue is to review the current knowledge on the implication of gap junctions in vascular function and most common cardiovascular diseases.
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DOI：
10.1083/jcb.129.3.805
发表时间：
1995-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Elfgang C;Eckert R;Lichtenberg-Fraté H;Butterweck A;Traub O;Klein RA;Hülser DF;Willecke K
通讯作者：
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DOI：
10.1152/ajpheart.00204.2005
发表时间：
2006-05-01
影响因子：
4.8
作者：
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通讯作者：
DePaola, N
影响因子：
20.1
作者：
Figueroa, XF;Paul, DL;Duling, BR
通讯作者：
Duling, BR
影响因子：
3.3
作者：
BRUZZONE, R;HAEFLIGER, JA;PAUL, DL
通讯作者：
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影响因子：
19.6
作者：
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通讯作者：
Lameire, NH