Cytogenetic determinants of male fertility.
Cytogenetic determinants of male fertility.
复制标题
男性生育能力的细胞遗传学决定因素。
DOI：
10.1093/humupd/dmn017
复制
发表时间：
2008-07
影响因子：
13.3
通讯作者：
Martin, R. H.
中科院分区：
文献类型：
--
作者：
Martin, R. H.
几十年来，细胞遗传学异常一直是男性不育的重要原因。从1978年到2008年的研究出版物，从PubMed，已经审查。这些研究极大地改善了我们对体细胞染色体异常（如易位、倒位和性染色体异常）及其对人类精子细胞遗传学组成的影响的了解。此外，我们还了解到，体细胞核型正常的不育男性有染色体异常精子和子女的风险增加。单精子分型和联会复合体分析等新技术为了解减数分裂重组与非整倍体精子产生之间的关系提供了有价值的见解。这些减数分裂研究也揭示了染色体配对和联会的错误，这在不育男性中更常见。这些研究使我们能够为不育患者提供更准确的信息，并进一步加深我们对男性不育原因的基本认识。
Cytogenetic abnormalities have been known to be important causes of male infertility for decades. Research publications from 1978 to 2008, from PubMed, have been reviewed. These studies have greatly improved our information on somatic chromosomal abnormalities such as translocations, inversions and sex chromosomal anomalies, and their consequences to the cytogenetic make-up of human sperm. Also, we have learned that infertile men with a normal somatic karyotype have an increased risk of chromosomally abnormal sperm and children. New techniques such as single sperm typing and synaptonemal complex analysis have provided valuable insight into the association between meiotic recombination and the production of aneuploid sperm. These meiotic studies have also unveiled errors of chromosome pairing and synapsis, which are more common in infertile men. These studies allow us to provide more precise information to infertile patients, and further our basic knowledge in the causes of male infertility.
登录
查看更多内容
影响因子：
1.6
作者：
Acar, H;Kilinç, M;Taskapu, H
通讯作者：
Taskapu, H
影响因子：
3.5
作者：
Amiel, A;Sardos-Albertini, F;Bartoov, B
通讯作者：
Bartoov, B
影响因子：
6.1
作者：
Anton, E;Blanco, J;Vidal, F
通讯作者：
Vidal, F
影响因子：
6.1
作者：
Baccetti, B;Bruni, E;Piomboni, P
通讯作者：
Piomboni, P
影响因子：
1.9
作者：
CHANDLEY, AC;MACLEAN, N;WATSON, GS
通讯作者：
WATSON, GS