Sodium-calcium exchange in plasma membrane vesicles.
Sodium-calcium exchange in plasma membrane vesicles.
复制标题
质膜囊泡中的钠钙交换。
DOI：
--
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发表时间：
1985
影响因子：
18.2
通讯作者：
K. Philipson
中科院分区：
文献类型：
--
作者：
K. Philipson
Reuter & Seitz 首先通过对豚鼠心房的钙通量测量推断出钠钙交换机制的存在 (47)。随后，由于 Ca 转运在细胞调节途径中的至关重要性，Na-Ca 交换受到了广泛关注。 Na-Ca 交换可能对于介导多种 Ca 依赖性反应至关重要，最突出的例子是心脏收缩状态的调节。此外，Na-Ca 交换可能在维持多种组织中低细胞 Ca 水平方面发挥作用。然而，细胞拥有多种 Ca 转运机制，并且在完整组织中通常不可能将 Na 或 Ca 通量明确分配给 Na-Ca 交换。最近开发的测量分离质膜囊泡中 Na-Ca 交换的技术极大地促进了研究，本综述将仅关注这些研究。目前，已经在多种组织的质膜囊泡中描述了 Na-Ca 交换，但最详细的测量是使用心脏肌膜的囊泡以及较小程度的脑质膜囊泡进行的。最近发表了描述在更完整的制剂中进行 Na-Ca 交换的开创性研究的评论 (6,12,25,46)。
The existence of a sodium-calcium exchange mechanism was first inferred from calcium-flux measurements on guinea-pig atria by Reuter & Seitz (47). Subsequently, N a-Ca exchange received much attention due to the critical importance of Ca transport in cellular regulatory pathways. Na-Ca exchange may be essential in mediating several Ca-dependent responses, with the most prominent example being regulation of the cardiac contractile state. In addi tion, Na-Ca exchange may play a role in maintaining the low cellular Ca level in several tissues. Cells possess multiple Ca-transport mechanisms, however, and unequivocal assignment of a Na or Ca flux to Na-Ca exhange is often not possible in intact tissues. The recent development of techniques for the measurement of Na-Ca exchange in isolated plasma membrane vesicles has greatly facilitated investigations, and this review will focus solely on these studies. Na-Ca exchange has now been described in plasma membrane vesicles from several tissues, but the most detailed measurements have been made using vesicles of cardiac sarcolemma and, to a lesser extent, brain plasma membrane. Reviews describing pioneering studies of Na-Ca exchange in more intact preparations have recently been published (6, 12, 25, 46).
具有改善的 Ca2+ 转运特性的犬心脏肌浆网的分离和表征。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chamberlain,BK;Levitsky,DO;Fleischer,S
通讯作者：
Fleischer,S
酒精和局部麻醉剂对脑突触膜囊泡中 Na 依赖性 Ca2 通量的影响。
影响因子：
5.8
作者：
Michaelis,ML;Michaelis,EK
通讯作者：
Michaelis,EK