ASHLEYS: automated quality control for single-cell Strand-seq data.

ASHLEYS: automated quality control for single-cell Strand-seq data.
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DOI:
10.1093/bioinformatics/btab221
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发表时间:
2021-10-11
期刊:
Bioinformatics (Oxford, England)
影响因子:
--
通讯作者:
Ebert P
Ebert P
中科院分区:
其他
文献类型:
--
作者:
Gros C;Sanders AD;Korbel JO;Marschall T;Ebert P

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Single-cell DNA template strand sequencing (Strand-seq) enables chromosome length haplotype phasing, construction of phased assemblies, mapping sister-chromatid exchange events and structural variant discovery. The initial quality control of potentially thousands of single-cell libraries is still done manually by domain experts. ASHLEYS automates this tedious task, delivers near-expert performance and labels even large datasets in seconds. github.com/friendsofstrandseq/ashleys-qc, MIT license. Supplementary data are available at Bioinformatics online.
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