Plasma S100A12 Concentrations in Peritoneal Dialysis Patients and Subclinical Chronic Inflammatory Disease
Plasma S100A12 Concentrations in Peritoneal Dialysis Patients and Subclinical Chronic Inflammatory Disease
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腹膜透析患者和亚临床慢性炎症性疾病的血浆 S100A12 浓度
DOI：
10.1111/j.1744-9987.2007.00537.x
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发表时间：
2008
影响因子：
1.9
通讯作者：
H. Matsubara
中科院分区：
文献类型：
--
作者：
Y. Uchiyama‐Tanaka;Y. Mori;A. Kosaki;Tatsuji Kimura;Misaki Moriishi;H. Kawanishi;H. Matsubara
翻译后摘要：S100 A12是晚期糖基化终产物的受体的配体。 研究表明，S100 A12诱导粘附分子的表达，并介导单核细胞/巨噬细胞的活化和迁移。循环S100 A12可能参与慢性炎症。我们先前报道了非胰岛素依赖型糖尿病和血液透析患者的S100 A12水平升高。高腹膜溶质转运率可能与包裹性腹膜硬化和死亡率相关。我们测定了腹膜透析患者的血浆S100 A12水平，并评估了腹膜透析患者血浆S100 A12水平升高与腹膜溶质转运率升高之间的可能关系。受试者包括36例患者（平均年龄± SE，46.0 ± 12.0岁），无明显感染，无恶性肿瘤，接受腹膜透析36.5 ± 3.9个月。 我们开发了一种酶联免疫吸附测定系统来测量血浆S100 A12水平。进行腹膜平衡试验，受试者被分类为高和高平均值（H）（n = 14）或低和低平均值（L）（n = 22）转运蛋白。 腹膜透析患者的血浆S100 A12浓度（21.6 ± 3.0 ng/mL）显著高于对照受试者（n = 42; 10.8 ± 1.0 ng/mL）。 H组血浆S100 A12浓度（28.2 ± 6.1 ng/mL）也高于L组（14.2 ± 2.0 ng/mL）。 这些结果表明，S100 A12可能是亚临床炎症的敏感标志物，并且S100 A12水平升高可能与腹膜溶质转运率高有关。
Abstract: S100A12 is a ligand for the receptor for advanced glycation end products. It has been shown that S100A12 induces expression of adhesion molecules, and mediates activation and migration of monocytes/macrophages. Circulating S100A12 may be involved in chronic inflammation. We previously reported increased S100A12 levels in patients with non‐insulin‐dependent diabetes mellitus and hemodialysis. A high peritoneal solute transport rate may be associated with encapsulating peritoneal sclerosis and mortality. We measured plasma S100A12 levels in peritoneal dialysis patients and evaluated a possible relation between the increased plasma S100A12 levels in peritoneal dialysis patients and the high peritoneal solute transport rate. Subjects included 36 patients (mean age ± SE, 46.0 ± 12.0 years) with no apparent infection and no malignancy who had been undergoing peritoneal dialysis for 36.5 ± 3.9 months. We developed an enzyme‐linked immunosorbent assay system to measure plasma S100A12 levels. A peritoneal equilibrium test was performed and subjects were categorized as high and high‐average (H) (n = 14) or low and low‐average (L) (n = 22) transporters. Plasma S100A12 concentrations were significantly higher in peritoneal dialysis patients (21.6 ± 3.0 ng/mL) than in control subjects (n = 42; 10.8 ± 1.0 ng/mL). Plasma S100A12 concentrations were also higher in the H group (28.2 ± 6.1 ng/mL) than in the L group (14.2 ± 2.0 ng/mL). These results suggest that S100A12 may be a sensitive marker of subclinical inflammation and that an increased S100A12 level may be related to the high peritoneal solute transport rate.
DOI：
10.1056/nejm199906173402418
发表时间：
1999-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Williams Kj;I. Tabas
通讯作者：
Williams Kj;I. Tabas
影响因子：
120.7
作者：
Pradhan, AD;Manson, JE;Ridker, PM
通讯作者：
Ridker, PM