Analytical method development and validation for the quantification of metaldehyde in soil.
Analytical method development and validation for the quantification of metaldehyde in soil.
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DOI：
10.1016/j.mex.2021.101482
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发表时间：
2021
期刊：
影响因子：
1.9
通讯作者：
Sinclair C
中科院分区：
文献类型：
--
作者：
Keighley N;Ramwell C;Werner D;Sinclair C
我们研究了从土壤样品中回收四聚乙醛。优化的LC-MS方法在一系列土壤类型中获得了可接受的四聚乙醛回收率（100- 132%，平均109%）。优化后的方法适用于高通量分析。以前公布的方法进行了调整，其可靠的定量土壤提取物中的四聚乙醛的分析。试验了不同的甲醇-水提取溶剂，但使用纯甲醇被证明是最可靠的方法规模缩小的方法。使用LC-MS进行四聚乙醛的分析。最初该方法存在信号的基质抑制问题。因此，该方法被进一步开发以克服这一挑战，以避免费力的清理方案的成本和时间需求。该方法的修改涉及使用BEH Phenyl色谱柱代替最初使用的C18色谱柱，并优化移动的相的梯度流。优化的LC-MS方法进行了验证，并用于进一步的研究应用。简而言之，
We investigated the recovery of metaldehyde from spiked soil samples. The optimized LC-MS method achieved acceptable metaldehyde recoveries (100–132%, 109% on average) for a range of soil types. The optimized method was suitable for high through-put analyzes. Previously published methods for the analysis of metaldehyde were adapted for its reliable quantification in soil extracts. Varied methanol-water extraction solvents were trialed, but the use of pure methanol proved to be the most reliable approach for the scaled down methodology. Analysis of metaldehyde was done using LC-MS. Initially the method had problems with matrix suppression of the signal. The method was therefore further developed to overcome this challenge to avoid the costs and time demands of laborious clean-up protocols. This modification to the method involved use of the BEH Phenyl column instead of the C18 column initially used, and optimization of the gradient flow of the mobile phase. The optimized LC-MS method was validated and used for further research applications. In brief,
影响因子：
5.7
作者：
Thomas JC;Helgason T;Sinclair CJ;Moir JWB
通讯作者：
Moir JWB