Autism risk in neonatal intensive care unit patients associated with novel heart rate patterns.
Autism risk in neonatal intensive care unit patients associated with novel heart rate patterns.
复制标题
新生儿重症监护病房的自闭症风险与新型心率模式相关的患者。
DOI：
10.1038/s41390-021-01381-1
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发表时间：
2021-12
影响因子：
3.6
通讯作者：
Fairchild KD
中科院分区：
文献类型：
--
作者：
Blackard KR;Krahn KN;Andris RT;Lake DE;Fairchild KD
Neonatal Intensive Care Unit (NICU) patients are at increased risk for autism spectrum disorder (ASD). Autonomic nervous system aberrancy has been described in children with ASD, and we aimed to identify heart rate (HR) patterns in NICU patients associated with eventual ASD diagnosis. This retrospective cohort study included NICU patients from 2009-2016 with archived HR data and follow-up beyond age 3 years. Medical records provided clinical variables and ASD diagnosis. HR data were compared in infants with and without ASD. Of 2371 patients, 88 had ASD, and 689,016 hours of data were analyzed. HR skewness (HRskw) was significantly different between ASD and control infants. Preterm infants at early postmenstrual ages (PMA) had negative HRskw reflecting decelerations, which increased with maturation. From 34-42 weeks PMA, positive HRskw toward accelerations was higher in males with ASD. In 931 males with at least 4 days of HR data, overall ASD prevalence was 5%, whereas 11% in the top 5th HRskw percentile had ASD. High HRskw in NICU males, perhaps representing autonomic imbalance, was associated with increased ASD risk. Further study is needed to determine whether HR analysis identifies highest risk infants who might benefit from earlier screening and therapies.
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影响因子：
1.7
作者：
Ming, Xue;Patel, Ritesh;Julu, Peter O.
通讯作者：
Julu, Peter O.
影响因子：
10.6
作者：
Pelphrey K
通讯作者：
Pelphrey K
早产儿的未成熟呼吸的临床关联：第1部分中心呼吸暂停。
影响因子：
3.6
作者：
Fairchild, Karen;Mohr, Mary;Paget-Brown, Alix;Tabacaru, Christa;Lake, Douglas;Delos, John;Moorman, Joseph Randall;Kattwinkel, John
通讯作者：
Kattwinkel, John
影响因子：
2.7
作者：
Cheshire, William P.
通讯作者：
Cheshire, William P.
影响因子：
3.6
作者：
Fairchild, Karen D.;Lake, Douglas E.;Sahni, Rakesh
通讯作者：
Sahni, Rakesh