Clinical associations of immature breathing in preterm infants: part 1-central apnea.
Clinical associations of immature breathing in preterm infants: part 1-central apnea.
复制标题
早产儿的未成熟呼吸的临床关联：第1部分中心呼吸暂停。
DOI：
10.1038/pr.2016.43
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发表时间：
2016-07
影响因子：
3.6
通讯作者：
Kattwinkel, John
中科院分区：
文献类型：
--
作者：
Fairchild, Karen;Mohr, Mary;Paget-Brown, Alix;Tabacaru, Christa;Lake, Douglas;Delos, John;Moorman, Joseph Randall;Kattwinkel, John
早产儿呼吸暂停（AOP）在极早产儿中几乎是普遍的，但在一个大的连续队列中，既没有系统地研究呼吸暂停负担，也没有研究其临床相关性。我们分析了从2009 - 2014年（n = 1211;> 50个婴儿年的数据）收集的所有妊娠<35周的NICU患者的连续床旁监护仪胸部阻抗和心电图波形以及血氧饱和度数据。使用经验证的自动算法识别"ABD"，定义为与心动过缓<100 bpm和氧饱和度下降<80%相关的中枢性呼吸暂停≥ 10秒。呼吸暂停事件的数量和持续时间随着胎龄（GA）和月经后年龄（PMA）的增加而减少。在出生时GA <31周的婴儿中，ABD更常见，但在考虑GA后，重度ROP、BPD或重度IVH的婴儿中并不更常见。在晚发性败血症和坏死性小肠结肠炎诊断的前一天，一些婴儿的ABD事件增加。许多婴儿在出院回家前一周继续经历短暂的ABD事件。在早产儿中，呼吸暂停事件的频率是GA和PMA的函数，呼吸暂停增加与急性病理条件相关，但与慢性病理条件无关。
Apnea of prematurity (AOP) is nearly universal among very preterm infants, but neither the apnea burden nor its clinical associations have been systematically studied in a large consecutive cohort. We analyzed continuous bedside monitor chest impedance and electrocardiographic waveforms and oxygen saturation data collected on all NICU patients <35 weeks gestation from 2009–2014 (n=1211; >50 infant-years of data). “ABDs”, defined as central apnea ≥10 sec associated with both bradycardia <100 bpm and oxygen desaturation <80%, were identified using a validated automated algorithm. Number and duration of apnea events decreased with increasing gestational age (GA) and post-menstrual age (PMA). ABDs were more frequent in infants <31 wks GA at birth but were not more frequent in those with severe ROP, BPD or severe IVH after accounting for GA. In the day before diagnosis of late-onset septicemia and necrotizing enterocolitis, ABD events were increased in some infants. Many infants continued to experience short ABD events in the week prior to discharge home. Frequency of apnea events is a function of GA and PMA in infants born preterm, and increased apnea is associated with acute but not with chronic pathologic conditions.
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DOI：
10.1073/pnas.0611468104
发表时间：
2007-06-05
影响因子：
11.1
作者：
Hofstetter, Annika O.;Saha, Sipra;Herlenius, Eric
通讯作者：
Herlenius, Eric
影响因子：
2.3
作者：
Darnall, Robert A.
通讯作者：
Darnall, Robert A.
影响因子：
8
作者：
Darnall, RA;Kattwinkel, J;Robinson, M
通讯作者：
Robinson, M
影响因子：
5.1
作者：
Di Fiore, Juliann M.;Bloom, Jeffrey N.;Martin, Richard J.
通讯作者：
Martin, Richard J.
影响因子：
5.2
作者：
BUTCHERPUECH, MC;HENDERSONSMART, DJ;EDWARDS, DA
通讯作者：
EDWARDS, DA