Severity-Dependent Effects of Parkinson's Disease on Perception of Visual and Vestibular Heading.
Severity-Dependent Effects of Parkinson's Disease on Perception of Visual and Vestibular Heading.
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DOI：
10.1002/mds.28352
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Shaikh AG
中科院分区：
文献类型：
--
作者：
Beylergil SB;Petersen M;Gupta P;Elkasaby M;Kilbane C;Shaikh AG
帕金森病（PD）通常影响视觉空间导航，导致姿势不稳定和跌倒。我们的总体目标是检查PD中控制视觉空间导航的视觉和前庭系统。我们假设PD影响前庭和视觉运动知觉，但程度不同。PD对运动知觉的影响取决于疾病的严重程度。双选项强迫选择任务在两个实验中客观地测量运动知觉。一项实验考察了平台整体运动对前庭运动感知的影响。第二个实验使用沉浸式虚拟现实护目镜测试视觉运动感知。我们发现，与轻度pd患者相比，晚期pd患者前庭感知的准确性、阈值和精度受损更严重。这些参数还与疾病持续时间、引起姿势不稳定和跌倒的整体轴向运动损伤以及平衡功能的主观评分有关。这种变化存在，但在视觉运动感知中不那么严重。我们得出结论，PD以严重依赖的方式影响视觉和前庭域的运动感知。疾病在前庭区域的影响比视觉区域更严重。
Parkinson’s disease (PD) commonly affects visuospatial navigation causing postural instability and falls. Our overarching aim was to examine the visual and vestibular systems governing visuospatial navigation in PD. We hypothesize that PD affects vestibular and visual motion perception but to a different extent. The effects of PD on motion perception are dependent on the severity of the disease. The two-alternative-forced-choice task objectively measured the motion perception during two experiments. One experiment examined the vestibular motion perception with en bloc movement of the platform. The second experiment tested the visual motion perception using an immersive virtual reality goggle. We found that accuracy, threshold, and precision of vestibular perception were more impaired in advanced-PD patients compared to those with a mild form of the disease. The parameters also correlated with the disease duration, overall axial motor impairment causing postural instability and falls, and subjective rating of the balance function. Such changes were present but less severe in visual motion perception. We conclude that PD affects motion perception in the visual and vestibular domains in a severity-dependent manner. The impact of the disease in the vestibular domain is more severe compared to the visual domain.
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影响因子：
3.7
作者：
Bertolini G;Wicki A;Baumann CR;Straumann D;Palla A
通讯作者：
Palla A
DOI：
10.4061/2011/908306
发表时间：
2011
期刊：
Parkinson's disease
影响因子：
--
作者：
Armstrong RA
通讯作者：
Armstrong RA
影响因子：
2.5
作者：
Hlavacka, F;Mergner, T;Bolha, B
通讯作者：
Bolha, B
影响因子：
5.8
作者：
Bostan, Andreea C.;Strick, Peter L.
通讯作者：
Strick, Peter L.
影响因子：
5.5
作者：
FITZPATRICK, R;MCCLOSKEY, DI
通讯作者：
MCCLOSKEY, DI