The cerebellum and basal ganglia are interconnected.

The cerebellum and basal ganglia are interconnected.
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DOI:
10.1007/s11065-010-9143-9
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发表时间:
2010-09
影响因子:
5.8
通讯作者:
Strick, Peter L.
Strick, Peter L.
中科院分区:
心理学2区
文献类型:
--
作者:
Bostan, Andreea C.;Strick, Peter L.

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小脑和基底神经节是主要的皮质下核团,主要通过与大脑皮层的相互作用来控制行为的多个方面。离散的多突触环将小脑和基底神经节与大脑皮层的多个区域连接起来。这些回路之间的相互作用传统上被认为主要发生在大脑皮层水平。在这里,我们回顾了一系列最近在非人灵长类动物的解剖学研究,挑战这一观点。我们发现,解剖学基板存在大量的相互作用之间的小脑和基底神经节。此外,我们还讨论了这些途径可能提供一个有用的框架,了解小脑的贡献,表现出两个典型的基底神经节疾病,帕金森氏病和肌张力障碍。
The cerebellum and the basal ganglia are major subcortical nuclei that control multiple aspects of behavior largely through their interactions with the cerebral cortex. Discrete multisynaptic loops connect both the cerebellum and the basal ganglia with multiple areas of the cerebral cortex. Interactions between these loops have traditionally been thought to occur mainly at the level of the cerebral cortex. Here, we review a series of recent anatomical studies in nonhuman primates that challenge this perspective. We show that the anatomical substrate exists for substantial interactions between the cerebellum and the basal ganglia. Furthermore, we discuss how these pathways may provide a useful framework for understanding cerebellar contributions to the manifestation of two prototypical basal ganglia disorders, Parkinson’s disease and dystonia.
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发表时间: 1999-03-01
期刊: BRAIN
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