International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma.
International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma.
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DOI：
10.3389/fimmu.2021.732006
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发表时间：
2021
影响因子：
7.3
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Mu S;Shi D;Ai L;Fan F;Peng F;Sun C;Hu Y
The International Prognostic Index (IPI) is widely used to discriminate the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). However, there is a significant need to identify novel valuable biomarkers in the context of targeted therapy, such as immune checkpoint blockade (ICB). Gene expression data and clinical DLBCL information were obtained from The Cancer Genome Atlas and Gene Expression Omnibus datasets. A total of 371 immune-related genes in DLBCL patients associated with different IPI risk groups were identified by weighted gene co-expression network analysis, and eight genes were selected to construct an IPI-based immune prognostic model (IPI-IPM). Subsequently, we analyzed the somatic mutation and transcription profiles of the IPI-IPM subgroups as well as the potential clinical response to immune checkpoint blockade (ICB) in IPI-IPM subgroups. The IPI-IPM was constructed based on the expression of CMBL, TLCD3B, SYNDIG1, ESM1, EPHA3, HUNK, PTX3, and IL12A, where high-risk patients had worse overall survival than low-risk patients, consistent with the results in the independent validation cohorts. The comprehensive results showed that high IPI-IPM risk scores were correlated with immune-related signaling pathways, high KMT2D and CD79B mutation rates, and upregulation of inhibitory immune checkpoints, including PD-L1, BTLA, and SIGLEC7, indicating a greater potential response to ICB therapy. The IPI-IPM has independent prognostic significance for DLBCL patients, which provides an immunological perspective to elucidate the mechanisms of tumor progression and sheds light on the development of immunotherapy for DLBCL.
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影响因子：
20.3
作者：
Chen, Yun-Wen;Hu, Xiao-Tong;Srivastava, Gopesh
通讯作者：
Srivastava, Gopesh
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
14.9
作者：
Colaprico A;Silva TC;Olsen C;Garofano L;Cava C;Garolini D;Sabedot TS;Malta TM;Pagnotta SM;Castiglioni I;Ceccarelli M;Bontempi G;Noushmehr H
通讯作者：
Noushmehr H
DOI：
10.3324/haematol.2010.037408
发表时间：
2011-07-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Cardesa-Salzmann, Teresa M.;Colomo, Luis;Campo, Elias
通讯作者：
Campo, Elias
影响因子：
2.4
作者：
Cui, Yuanbo;Guo, Wenna;Guan, Fangxia
通讯作者：
Guan, Fangxia