Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool.
Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool.
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DOI：
10.3389/fmolb.2023.1127690
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发表时间：
2023
影响因子：
5
通讯作者：
中科院分区：
文献类型：
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作者：
细胞表达数百种依赖铁的酶，这些酶依赖于铁辅因子血红素、铁硫簇和单核或双核铁中心的活性。细胞需要用于铁辅因子向其同源酶的组装和分布的系统。在哺乳动物细胞中，已经鉴定并表征了参与铁离子在细胞质中的结合和运输的蛋白质，称为细胞质铁伴侣。第一个确定的铁分子伴侣，聚C结合蛋白1（PCBP 1），也已经在小鼠中研究了专门用于铁处理的组织中的条件性缺失的遗传模型。铁在小鼠组织中的运输的研究已经有必要开发新的方法，这揭示了PCBP1在细胞溶质铁的管理中的新作用。这些方法可以应用于研究其他营养金属在哺乳动物中的使用。
Cells express hundreds of iron-dependent enzymes that rely on the iron cofactors heme, iron-sulfur clusters, and mono-or di-nuclear iron centers for activity. Cells require systems for both the assembly and the distribution of iron cofactors to their cognate enzymes. Proteins involved in the binding and trafficking of iron ions in the cytosol, called cytosolic iron chaperones, have been identified and characterized in mammalian cells. The first identified iron chaperone, poly C-binding protein 1 (PCBP1), has also been studied in mice using genetic models of conditional deletion in tissues specialized for iron handling. Studies of iron trafficking in mouse tissues have necessitated the development of new approaches, which have revealed new roles for PCBP1 in the management of cytosolic iron. These approaches can be applied to investigate use of other nutrient metals in mammals.
通过稳定同位素标记技术评估中国成年人铁的生理需求
影响因子：
4.5
作者：
Cai J;Ren T;Zhang Y;Wang Z;Gou L;Huang Z;Wang J;Piao J;Yang X;Yang L
通讯作者：
Yang L
影响因子：
4.8
作者：
通讯作者：
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