Variations in stromal signatures in breast and colorectal cancer metastases.
Variations in stromal signatures in breast and colorectal cancer metastases.
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DOI：
10.1002/path.2738
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发表时间：
2010-10
影响因子：
7.3
通讯作者：
West, Robert
中科院分区：
文献类型：
--
作者：
Webster, Jonathan A.;Beck, Andrew H.;Sharma, Mimansa;Espinosa, Inigo;Weigelt, Britta;Schreuder, Marthe;Montgomery, Kelli D.;Jensen, Kristin C.;van de Rijn, Matt;West, Robert
肿瘤微环境（TME）在肿瘤的生存和生长中起着重要的作用，但对原发性肿瘤及其转移灶中不同基质反应模式之间的保存程度知之甚少。我们以前已经确定了乳腺癌成纤维细胞（aka DTF）和巨噬细胞反应（aka CSF1）中两种不同基质特征的基因表达谱，并发现它们与临床病理特征（包括结果）相关。在这项研究中，我们比较了DTF成纤维细胞和CSF 1巨噬细胞间质反应模式在原发性乳腺癌和结直肠癌，他们匹配的淋巴结转移。在乳腺癌和结直肠癌中，通过免疫组织化学标记物评估，原发性肿瘤中的CSF 1巨噬细胞签名与匹配的淋巴结转移之间存在显著的正相关性。对于DTF成纤维细胞特征没有观察到这种相关性。在对两个已发表的基因表达微阵列数据集的独立分析中看到了类似的结果。这些间质反应模式从原发到转移的变化揭示了TME中肿瘤细胞和非肿瘤细胞之间的关系。转移灶中CSF 1巨噬细胞反应模式的保留支持靶向癌症中的CSF 1途径。
The tumor microenvironment (TME) plays an important role in tumor survival and growth but little is known about the degree of preservation between different stromal response patterns found in primary tumors and their metastases. We have previously identified gene expression profiles for two distinct stromal signatures in breast carcinoma of fibroblast (aka DTF) and macrophage response (aka CSF1) and found them to be correlated with clinicopathologic features including outcome. In this study, we compare the DTF fibroblast and CSF1 macrophage stromal response patterns in primary breast and colorectal cancers to their matched lymph node metastases. In both breast and colorectal cancer, there was a significant, positive correlation between the CSF1 macrophage signature in the primary tumors and the matched lymph node metastases as assessed by immunohistochemical markers. No such correlation was observed for the DTF fibroblast signature. A similar result was seen in independent analysis of two published gene expression microarray datasets. The variations of these stromal reaction patterns from the primary to the metastasis shed light on the relationship between the neoplastic cells and the non-neoplastic cells in the TME. The preservation of the CSF1 macrophage response pattern in metastases lends support to targeting the CSF1 pathway in cancer.
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影响因子：
3.8
作者：
Sharma, M.;Beck, A. H.;Webster, J. A.;Espinosa, I.;Montgomery, K.;Varma, S.;van de Rijn, M.;Jensen, K. C.;West, R. B.
通讯作者：
West, R. B.
DOI：
10.1158/1078-0432.ccr-08-1283
发表时间：
2009-02-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Beck AH;Espinosa I;Edris B;Li R;Montgomery K;Zhu S;Varma S;Marinelli RJ;van de Rijn M;West RB
通讯作者：
West RB
确定乳腺癌中基质特征的测定。
影响因子：
9.8
作者：
通讯作者：
--
影响因子：
3.4
作者：
Li, Jian;Gromov, Pavel;Celis, Julio E.
通讯作者：
Celis, Julio E.
影响因子：
2.6
作者：
Hanada, T;Nakagawa, M;Nomura, Y
通讯作者：
Nomura, Y