Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.
Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.
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DOI：
10.1016/j.bbrc.2013.08.091
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发表时间：
2013-10-04
影响因子：
3.1
通讯作者：
Hoe, Hyang-Sook
中科院分区：
文献类型：
--
作者：
Sohn, Young In;Lee, Nathanael J.;Chung, Andrew;Saavedra, Juan M.;Turner, R. Scott;Pak, Daniel T. S.;Hoe, Hyang-Sook
Recent studies demonstrated that the antihypertensive drug Valsartan improved spatial and episodic memory in mouse models of Alzheimer’s Disease (AD) and human subjects with hypertension. However, the molecular mechanism by which Valsartan can regulate cognitive function is still unknown. Here, we investigated the effect of Valsartan on dendritic spine formation in primary hippocampal neurons, which is correlated with learning and memory. Interestingly, we found that Valsartan promotes spinogenesis in developing and mature neurons. In addition, we found that Valsartan increases the puncta number of PSD-95 and trends toward an increase in the puncta number of synaptophysin. Moreover, Valsartan increased the cell surface levels of AMPA receptors and selectively altered the levels of spinogenesis-related proteins, including CaMKIIα and phospho-CDK5. These data suggest that Valsartan may promote spinogenesis by enhancing AMPA receptor trafficking and synaptic plasticity signaling.
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影响因子：
2.3
作者：
Wang Y;Song Y;Suo M;Jin X;Tian G
通讯作者：
Tian G
影响因子：
34.7
作者：
Lisman, John;Yasuda, Ryohei;Raghavachari, Sridhar
通讯作者：
Raghavachari, Sridhar
DOI：
10.1083/jcb.200805132
发表时间：
2008-12-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Nikonenko I;Boda B;Steen S;Knott G;Welker E;Muller D
通讯作者：
Muller D
DOI：
10.1161/hypertensionaha.112.195511
发表时间：
2012-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Carnevale D;Mascio G;D'Andrea I;Fardella V;Bell RD;Branchi I;Pallante F;Zlokovic B;Yan SS;Lembo G
通讯作者：
Lembo G
影响因子：
3.3
作者：
Toyoda H;Zhao MG;Ulzhöfer B;Wu LJ;Xu H;Seeburg PH;Sprengel R;Kuner R;Zhuo M
通讯作者：
Zhuo M