Depression and immunity: a role for T cells?
Depression and immunity: a role for T cells?
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DOI：
10.1016/j.bbi.2009.09.009
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发表时间：
2010-01
影响因子：
15.1
通讯作者：
Miller, Andrew H.
中科院分区：
文献类型：
--
作者：
Miller, Andrew H.
免疫系统在人类抑郁症的病理生理学中的潜在作用受到了广泛关注。虽然先天免疫应答的激活目前在研究领域占主导地位，但在抑郁症患者中的早期研究表明获得性免疫应答，特别是T细胞应答受损，可能需要进一步考虑。有趣的数据表明，活化的T细胞可能在应激和炎症的背景下发挥重要的神经保护作用。例如，通过用中枢神经系统（CNS）特异性抗原免疫产生自身反应性T细胞已显示逆转应激诱导的海马神经发生减少以及啮齿动物中的抑郁样行为。此外，已经发现在压力之后T细胞向大脑的运输（部分地与糖皮质激素相关）减少压力诱导的焦虑样行为。数据表明，调节性T细胞也可能通过下调慢性炎症反应在抑郁症中发挥作用。基于T细胞在应激和炎症期间可能有助于神经保护和抗炎功能的概念，受损的T细胞功能可能直接导致抑郁症的发展。事实上，对细胞凋亡的敏感性增加以及对糖皮质激素的反应性降低，不仅可能降低抑郁症患者中T细胞的可用性，而且可能降低它们响应相关神经内分泌或免疫刺激而向大脑运输的能力。T细胞病理学的进一步阐明可能会导致对免疫系统对抑郁症的贡献的新见解。此外，增强T细胞功能可能是治疗抑郁症的另一种策略。
Much attention has been paid to the potential role of the immune system in the pathophysiology of major depression in humans. While activation of innate immune responses currently dominates the research landscape, early studies in depressed patients demonstrating impairment in acquired immune responses, in particular T cell responses, may warrant further consideration. Intriguing data suggest that activated T cells may play an important neuroprotective role in the context of both stress and inflammation. For example, generation of autoreactive T cells through immunization with central nervous system (CNS) specific antigens has been shown to reverse stress-induced decreases in hippocampal neurogenesis as well as depressive-like behavior in rodents. In addition, trafficking of T cells to the brain following stress, in part related to glucocorticoids, has been found to reduce stress-induced anxiety-like behavior. Data indicate that T regulatory cells may also play a role in depression through downregulation of chronic inflammatory responses. Based on the notion that T cells may subserve neuroprotective and anti-inflammatory functions during stress and inflammation, impaired T cell function may directly contribute to the development of depression. Indeed, increased sensitivity to apoptosis as well as reduced responsiveness to glucocorticoids, may not only decrease the availability of T cells in depressed patients, but also may reduce their capacity to traffic to the brain in response to relevant neuroendocrine or immune stimuli. Further elucidation of T cell pathology may lead to new insights into immune system contributions to depression. Moreover, enhancement of T cell function may represent an alternative strategy to treat depression.
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DOI：
10.1084/jem.185.9.1573
发表时间：
1997-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cope AP;Liblau RS;Yang XD;Congia M;Laudanna C;Schreiber RD;Probert L;Kollias G;McDevitt HO
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McDevitt HO
影响因子：
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作者：
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发表时间：
2006-05-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
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影响因子：
6.5
作者：
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影响因子：
3.3
作者：
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