Insights Into Development and Progression of Idiopathic Pulmonary Fibrosis From Single Cell RNA Studies.
Insights Into Development and Progression of Idiopathic Pulmonary Fibrosis From Single Cell RNA Studies.
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DOI：
10.3389/fmed.2020.611728
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发表时间：
2020
影响因子：
3.9
通讯作者：
Frick M
中科院分区：
文献类型：
--
作者：
Nemeth J;Schundner A;Frick M
特发性肺纤维化（IPF）是一种进行性和致死性肺部疾病，治疗选择有限。目前的模型表明，慢性或重复的肺泡上皮细胞的“微损伤”导致成纤维细胞的活化和增殖以及过量的细胞外基质（ECM）沉积。近年来，IPF中肺泡II型（ATII）上皮细胞稳态的破坏和间充质细胞群的特征受到了特别关注。来自单细胞RNA测序（scRNAseq）分析的新数据揭示了ATII细胞祖细胞功能障碍的改变和纤维化肺内间充质细胞的多样性。在这篇小综述中，我们总结了最近人类scRNAseq研究的数据。我们的目的是整理目前关于IPF发生和进展中细胞可塑性和异质性的知识，以及药物治疗对转录变化的影响。最后，我们对未来的挑战和大规模测序研究在IPF新疗法开发中的前景进行了简要展望。
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited therapeutic options. The current model suggests that chronic or repetitive “micro-injuries” of the alveolar epithelium lead to activation and proliferation of fibroblasts and excessive extracellular matrix (ECM) deposition. Disruption of alveolar type II (ATII) epithelial cell homeostasis and the characteristics of mesenchymal cell populations in IPF have received particular attention in recent years. Emerging data from single cell RNA sequencing (scRNAseq) analysis shed novel light on alterations in ATII cell progenitor dysfunction and the diversity of mesenchymal cells within the fibrotic lung. Within this minireview, we summarize the data from most recent human scRNAseq studies. We aim to collate the current knowledge on cellular plasticity and heterogeneity in the development and progression of IPF, effects of drug treatment on transcriptional changes. Finally, we provide a brief outlook on future challenges and promises for large scale sequencing studies in the development of novel therapeutics for IPF.
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影响因子：
16.6
作者：
Jain, Rajan;Barkauskas, Christina E.;Takeda, Norifumi;Bowie, Emily J.;Aghajanian, Haig;Wang, Qiaohong;Padmanabhan, Arun;Manderfield, Lauren J.;Gupta, Mudit;Li, Deqiang;Li, Li;Trivedi, Chinmay M.;Hogan, Brigid L. M.;Epstein, Jonathan A.
通讯作者：
Epstein, Jonathan A.
DOI：
10.1165/rcmb.2017-0037ma
发表时间：
2017-11-01
影响因子：
6.4
作者：
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通讯作者：
Zemans, Rachel L.
影响因子：
5
作者：
Chilosi, M;Poletti, V;Doglioni, C
通讯作者：
Doglioni, C
影响因子：
64.8
作者：
La Manno G;Soldatov R;Zeisel A;Braun E;Hochgerner H;Petukhov V;Lidschreiber K;Kastriti ME;Lönnerberg P;Furlan A;Fan J;Borm LE;Liu Z;van Bruggen D;Guo J;He X;Barker R;Sundström E;Castelo-Branco G;Cramer P;Adameyko I;Linnarsson S;Kharchenko PV
通讯作者：
Kharchenko PV
影响因子：
6
作者：
Barron, Luke;Gharib, Sina A.;Duffield, Jeremy S.
通讯作者：
Duffield, Jeremy S.