Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease.
Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease.
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DOI：
10.1097/med.0000000000000085
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Nikolajczyk BS
中科院分区：
文献类型：
--
作者：
Strissel KJ;Denis GV;Nikolajczyk BS
To summarize current work identifying inflammatory components that underlie associations between obesity-associated type 2 diabetes (T2D) and coronary artery disease (CAD). Recent studies implicate immune cells as drivers of pathogenic inflammation in human T2D. Inflammatory lymphocytes characterize unhealthy adipose tissue (AT), but regional adipose volume, primarily visceral and pericardial fat; also predict severity and risk for obesity-associated CAD. Having a greater understanding of shared characteristics between inflammatory cells from different AT depots and a more accessible tissue such as blood will facilitate progress towards clinical translation of our appreciation of obesity as an inflammatory disease. Obesity predisposes inflammation and metabolic dysfunction through multiple mechanisms, but these mechanisms remain understudied in humans. Studies of obese subjects have identified disproportionate impacts of specific T cell subsets in metabolic diseases like T2D. Based on demonstration that AT inflammation is depot-specific, analysis of adiposity by waist-to-hip ratio or magnetic resonance imaging (MRI) will increase interpretive value of lymphocyte-focused studies and aid clinicians in determining which obese individuals are at highest risk for CAD. New tools to combat obesity-associated CAD and other co-morbidities will stem from identification of immune cell-mediated inflammatory networks that are amenable to pharmacological interventions.
影响因子：
8.8
作者：
Matthews, N
通讯作者：
Matthews, N