From Wingspread to CLARITY: a personal trajectory.

From Wingspread to CLARITY: a personal trajectory.
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DOI:
10.1038/s41574-020-00460-3
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发表时间:
2021-04
影响因子:
40.5
通讯作者:
Sonnenschein, Carlos
Sonnenschein, Carlos
中科院分区:
医学1区
文献类型:
--
作者:
Soto, Ana M.;Schaeberle, Cheryl M.;Sonnenschein, Carlos

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自Wingspread会议提出内分泌干扰概念以来的三十年里,我们目睹了这一多学科领域的发展,以及显示内分泌干扰化学品对健康有害影响的证据的积累。只是在过去十年中,监管措施才发生了一些变化,尽管变化缓慢。在这个角度来看,我们解决了一些历史点,关于内分泌干扰领域的到来和概念的变化,内分泌干扰带来的。我们还提供了我们个人的回忆,由我们偶然发现的塑料中的雌激素活性所引发的事件,这是内分泌干扰领域的创始人事件。这段回忆以“为科学本身而科学”和“监管科学”之间不一致的一个例子结束,并引导我们提供一个可以用路德维希·玻尔兹曼的座右铭概括的观点:“没有什么比一个好的理论更实用”。
In the three decades since endocrine disruption was conceptualized at the Wingspread Conference, we have witnessed the growth of this multidisciplinary field and the accumulation of evidence showing the deleterious health effects of endocrine-disrupting chemicals. It is only within the past decade that, albeit slowly, some changes regarding regulatory measures have taken place. In this Perspective, we address some historical points regarding the advent of the endocrine disruption field and the conceptual changes that endocrine disruption brought about. We also provide our personal recollection of the events triggered by our serendipitous discovery of oestrogenic activity in plastic, a founder event in the field of endocrine disruption. This recollection ends with the CLARITY study as an example of a discordance between ‘science for its own sake’ and ‘regulatory science’ and leads us to offer a perspective that could be summarized by the motto attributed to Ludwig Boltzmann: “Nothing is more practical than a good theory”.
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