Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation.
Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation.
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DOI：
10.1016/j.ajog.2010.06.001
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发表时间：
2010-10
影响因子：
9.8
通讯作者：
Downs L
中科院分区：
文献类型：
--
作者：
Hui SK;Khalil A;Zhang Y;Coghill K;Le C;Dusenbery K;Froelich J;Yee D;Downs L
应用诊断性CT扫描测量妇科肿瘤患者的体积骨密度（vBMD）。在一项回顾性研究中，对40名接受化疗或放疗的患者进行了为期一年的脊柱和股骨颈（FN） vBMD测量。化疗、放疗及放化疗联合治疗后骨质流失明显（p=0.0211）。一年内，化疗组L1L2脊柱和FN椎体骨密度（±SE）降低的百分比分别为15.9%（±5.67）和10.4%（±4.06）；分别为11%（±5.68）和15.8%（±2.56）；联合治疗组分别为21.0%（±7.03）和3.6%（±3.3.7）。大多数妇女在治疗后立即出现明显的骨质流失，并持续或恶化。接受化疗或放疗的妇科癌症患者会出现即刻和长期的骨质流失；因此，治疗前和治疗后监测骨质流失对这些患者很重要。
To measure volumetric bone mineral density (vBMD) using diagnostic CT scans in gynecologic oncology patients. In a retrospective study, spine and femoral neck (FN) vBMD was measured for one year in 40 patients receiving chemotherapy or radiation. There is significant bone loss after chemotherapy, radiation and combination of radiation and chemotherapy (p=0.0211). In one year, the percent reduction in vBMD (±SE) at L1L2 spine and the FN was a 15.9 % (±5.67) and 10.4 % (± 4.06) in chemotherapy; was 11% (±5.68) and 15.8 % (±2.56) in radiation; and was 21.0 % (±7.03) and 3.6 % (±3.3.7) in combined therapy group. Bone loss was evident immediately after treatment and persisted or worsened in most women. Gynecologic cancer patients treated with chemotherapy or radiation experience immediate and prolonged bone loss; thus, pre- and post-treatment monitoring of bone loss is important in these patients.
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影响因子：
120.7
作者：
Baxter, NN;Habermann, EB;Virnig, BA
通讯作者：
Virnig, BA
影响因子：
7.2
作者：
Douchi, T;Kosha, S;Nagata, Y
通讯作者：
Nagata, Y
影响因子：
168.9
作者：
CUMMINGS, SR;BLACK, DM;VOGT, TM
通讯作者：
VOGT, TM
DOI：
10.1002/mpo.10338
发表时间：
2003-09-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
Hopewell, JW
通讯作者：
Hopewell, JW
影响因子：
4
作者：
ROSS, PD;GENANT, HK;WASNICH, RD
通讯作者：
WASNICH, RD