Effects of acute alcohol intoxication and paroxetine on aggression in men.
Effects of acute alcohol intoxication and paroxetine on aggression in men.
复制标题
急性酒精中毒和帕罗西汀对男性攻击性的影响。
DOI：
10.1111/j.1530-0277.2008.00872.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Coccaro,EmilF
中科院分区：
文献类型：
--
作者：
McCloskey,MichaelS;Berman,MitchellE;Echevarria,DavidJ;Coccaro,EmilF
Background:The purpose of this study was to examine the role of the serotonin (5‐HT) system in alcohol‐related aggression.Methods:Specifically, we experimentally examined the effects of 5‐HT augmentation on alcohol‐related aggression in men (n=56). After consuming either alcohol (mean blood alcohol concentration of 0.10%) or a placebo (no alcohol) drink, and taking either 20 mg of paroxetine (Paxil®) or a placebo pill, participants were provided the opportunity to administer electric shock to a (faux) opponent during a task disguised as a reaction‐time game. Aggression was defined as the intensity of shock chosen and the frequency with which an extreme (clearly painful) shock was chosen. We predicted that 5‐HT augmentation would be associated with lower aggressive behavior overall, and also reduce the aggression facilitating effects of acute alcohol intoxication.Results:The results indicated that alcohol intoxication increased aggression, particularly under low provocation. Paroxetine decreased aggression, particularly during high provocation. These effects, however, occurred independently of each other.Conclusions:The effect of alcohol on extreme aggression was moderated by previous aggression history, with more aggressive individuals showing greater alcohol‐related increases in extreme aggression.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
酒精近视的两个方面：心理压力的注意力调节。
影响因子：
4.6
作者：
Josephs,RA;Steele,CM
通讯作者：
Steele,CM
DOI：
10.4088/jcp.v63n0613a
发表时间：
2002
期刊：
The Journal of Clinical Psychiatry
影响因子：
--
作者：
D. Garver
通讯作者：
D. Garver
影响因子：
4.3
作者：
Reynolds, B;Ortengren, A;de Wit, H
通讯作者：
de Wit, H
氟西汀和人格障碍受试者的冲动攻击行为。
影响因子：
--
作者：
Coccaro,EF;Kavoussi,RJ
通讯作者：
Kavoussi,RJ