Addiction Biomarkers: Dimensional Approaches to Understanding Addiction.

Addiction Biomarkers: Dimensional Approaches to Understanding Addiction.
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DOI:
10.1016/j.molmed.2017.12.007
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发表时间:
2018-03
影响因子:
13.6
通讯作者:
Goldman D
Goldman D
中科院分区:
医学1区
文献类型:
--
作者:
Kwako LE;Bickel WK;Goldman D

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在理解精神疾病方面,向维度方法发展的趋势也可能适用于成瘾性疾病。我们对成瘾的神经生物学理解的进步可以为这些努力提供信息。此外,成瘾的维度方法,如提出的成瘾神经临床评估(ANA),可用于识别新的成瘾生物标志物,并改进目前存在的生物标志物。这些生物标志物来源于对成瘾神经生物学和行为表型的理解,代表了对酒精相关生物标志物的传统标志物的偏离,例如肝功能测试(LFT)。我们认为,一个潜在的成瘾相关生物标志物是成瘾病理学,发现与不同物质的成瘾相关,并且可以通过使用情节性未来思维提供修改的目标。
Trends towards dimensional approaches in understanding psychiatric disorders may also be applied to addictive disorders. Advances in our understanding of the neurobiology of addiction can inform these efforts. Furthermore, dimensional approaches to addiction, such as the proposed Addictions Neuroclinical Assessment (ANA), may be used in identifying novel addiction biomarkers, and refining ones that currently exist. These biomarkers, derived from both an understanding of the neurobiology of addiction and behavioral phenotypes, represent a departure from traditional markers of alcohol-relevant biomarkers, such as tests of liver function (LFTs). We posit that a potential addictionrelevant biomarker is reinforcer pathology, found to be relevant across addictions to different substances, and which may offer a target for modification through the use of episodic future thinking.
成瘾神经临床评估:基于神经科学的成瘾性疾病框架。
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