Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast
Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast
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Cdc42 促进裂殖酵母胞质分裂过程中用于隔膜合成的 Bgs1 募集和用于细胞分离的葡聚糖酶定位
DOI：
10.1080/21541248.2020.1743926
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Das, Maitreyi E.
中科院分区：
文献类型：
--
作者：
Onwubiko, Udo N.;Rich-Robinson, Julie;Mustaf, Rose Albu;Das, Maitreyi E.
裂殖酵母的胞质分裂涉及肌动球蛋白环收缩，同时进行隔膜合成，随后进行隔膜消化，导致细胞分离。最近的一份报告表明，内吞作用是必要的隔膜合成和细胞分离。保守的GTdR Cdc42是膜运输所需的，并促进内吞作用。Cdc42被鸟嘌呤核苷酸交换因子（GEF）激活。Cdc42 GEFs已被证明可以促进隔片合成的及时启动和适当的隔片形态。在这里，我们表明，Cdc42促进招聘的主要初级隔膜合成酶BGS 1和随之而来的环收缩。Cdc42也需要适当的定位的隔膜消化葡聚糖酶在分裂网站。因此，Cdc42需要促进胞质分裂过程中的多个步骤。
Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum synthesis followed by septum digestion resulting in cell separation. A recent report indicates that endocytosis is required for septum synthesis and cell separation. The conserved GTPase Cdc42 is required for membrane trafficking and promotes endocytosis. Cdc42 is activated by Guanine nucleotide exchange factors (GEFs). Cdc42 GEFs have been shown to promote timely initiation of septum synthesis and proper septum morphology. Here we show that Cdc42 promotes the recruitment of the major primary septum synthesizing enzyme Bgs1 and consequent ring constriction. Cdc42 is also required for proper localization of the septum digesting glucanases at the division site. Thus, Cdc42 is required to promote multiple steps during cytokinesis.
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影响因子：
4
作者：
Udo N. Onwubiko;P. Mlynarczyk;Bin Wei;Julius Habiyaremye;Amanda Clack;S. Abel;Maitreyi E. Das
通讯作者：
Udo N. Onwubiko;P. Mlynarczyk;Bin Wei;Julius Habiyaremye;Amanda Clack;S. Abel;Maitreyi E. Das
影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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